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Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein. OX40L is expressed by DCs, macrophages and B cells and signals via its cognate receptor OX40 which is mainly expressed on APCs. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells. It is a cytokine that binds to TNFRSF4, Co-stimulates T-cell proliferation and cytokine production. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells.
别名 Tumor necrosis factor ligand 2B, TNFSF4, OX-40L
Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein. OX40L is expressed by DCs, macrophages and B cells and signals via its cognate receptor OX40 which is mainly expressed on APCs. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells. It is a cytokine that binds to TNFRSF4, Co-stimulates T-cell proliferation and cytokine production. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells.

| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 μg | ¥ 343 | 2-4周 | |
| 10 μg | ¥ 550 | 2-4周 | |
| 20 μg | ¥ 878 | 2-4周 | |
| 50 μg | ¥ 1,670 | 2-4周 | |
| 100 μg | ¥ 3,120 | 2-4周 | |
| 200 μg | ¥ 5,890 | 2-4周 | |
| 500 μg | ¥ 13,700 | 2-4周 | |
| 1 mg | ¥ 20,500 | 2-4周 |
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| 产品描述 | Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein. OX40L is expressed by DCs, macrophages and B cells and signals via its cognate receptor OX40 which is mainly expressed on APCs. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells. It is a cytokine that binds to TNFRSF4, Co-stimulates T-cell proliferation and cytokine production. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells. |
| 生物活性 | Immobilized Cynomolgus/Rhesus macaque OX40 Ligand, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Human OX40, hFc Tag with the EC50 of 18.7 ng/ml determined by ELISA. |
| 研究背景 | Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein. OX40L is expressed by DCs, macrophages and B cells and signals via its cognate receptor OX40 which is mainly expressed on APCs. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells. It is a cytokine that binds to TNFRSF4, Co-stimulates T-cell proliferation and cytokine production. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells. |
| 种属 | Cynomolgus/Rhesus macaque |
| 表达系统 | HEK293 Cells |
| 标签 | N-His |
| 蛋白编号 | A0A2K5TTN0(Cynomolgus) / A0A1D5QQH7(Rhesus macaque) |
| 蛋白构建 | Gln81-Leu213 (Cynomolgus) / Gln51-Leu183 (Rhesus macaque) |
| 蛋白纯度 | > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC |
| 缓冲液 | Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| 复溶方法 | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| 别名 | Tumor necrosis factor ligand 2B, TNFSF4, OX-40L |
| 内毒素 | <1 EU/µg as determined by LAL test. |
| 分子量 | 17.01 kDa (predicted); 25-38 kDa (due to glycosylation); 60-70 kDa (SEC-MALS) |
| 运输方式 | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| 存储 | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. 实际储存温度请以COA为准 |
对于不同动物的给药剂量换算,您也可以参考 更多