Name: FZ-A038
Brand: TargetMol
SKU: T9901A-490
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

待询

5 mg

待询

生物活性

产品描述	FZ-A038 is a humanized monoclonal antibody targeting Delta-like ligand 3 (DLL3). DLL3 is specifically overexpressed in small cell lung cancer (SCLC) and neuroendocrine carcinomas, with its signaling activation involving proteolytic cleavage by Gamma-secretase. FZ-A038 binds to the extracellular domain of DLL3 with high affinity and induces rapid internalization. As the antibody component of the antibody-drug conjugate (ADC) FZ-AD005, it delivers a conjugated Topoisomerase I inhibitor (an exatecan derivative) into tumor cells via internalization, inducing DNA damage and exerting potent anti-tumor activity.
体外活性	FZ-A038 高亲和力结合人 DLL3。在 NCI-H69 和 NCI-H187 细胞中，该抗体复合物结合后快速内化。其 ADC 形式 (FZ-AD005) 具有强效细胞毒性 (IC50 达亚纳摩尔级)，通过诱导 DNA 双链断裂引起 DLL3+ 肿瘤细胞凋亡 [1]。
体内活性	在利用小细胞肺癌和神经内分泌癌异种移植小鼠模型进行的药理研究中，系统给予含有 FZ-A038 臂的 FZ-AD005 ADC 导致显著且持久的肿瘤消退 [1]。
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型	IgG1-LFLE-PS

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	Q9NYJ7
靶点	DLL3

储存&溶解度

存储	store at low temperature \| -20°C for 2 years, 4°C for 1 year \| Shipping with blue ice.

FZ-A038