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肝脏毒性化合物库

肝脏毒性化合物库

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产品编号 L5510 Drug-induced Liver Injury (DILI) Compound Library
  库化合物信息   Excel SDF

药物性肝损伤(drug-induced liver injury,DILI)是一种常见的药物不良反应,在药物性靶器官毒性中仅次于心脏毒性,是导致药物研发终止或从市场撤回的重要原因之一。因此,药物的肝脏毒性正日益受到医学界、社会公众和药监部门的广泛关注和重视。 DILI 已被证实是一个由多种机制参与的复杂病理过程,其中包括肝脏的结构和功能完整性的直接损害(例如线粒体功能障碍);产生改变肝细胞结构和功能的代谢产物;产生能与肝蛋白结合的反应性药物代谢产物,从而产生新的抗原性药物-蛋白质加合物,这些新的加合物被宿主的防御系统所针对(半抗原假说),并引发损害肝脏的全身超敏反应(即药物过敏)。 TargetMol 肝脏毒性化合物库包含 1040 个能够引起肝损伤的化合物,这些化合物包括抗肿瘤药物、抗生素药物、抗精神疾病药物、心血管药物等,是开展 DILI 和相关药物毒理学研究的有力工具,对了解 DILI 发病机制,找到预测其发生、进展的生物标志物,以及有效防控 DILI 具有重要价值。

TargetMol的所有产品和服务仅用于科学研究,不能被用于人体,我们也不向个人提供产品和服务。
规格
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
如果上述化合物库无法满足您的需求,您可发送邮件至tech@targetmol.com咨询我们的技术专员,为您量身定制专属化合物库!
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产品描述

  • 1040个肝脏毒性化合物的特有集合,可用于高通量、高内涵筛选,是毒理学研究的良好工具;
  • 包括抗肿瘤药物、抗生素药物、抗精神疾病药物、心血管药物等;
  • 具有多样化的肝脏毒性,包括脂肪变性,线粒体毒性,胆汁淤积效应,超敏反应等;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。

化合物库定制

TargetMol的化合物可以高度定制! 了解更多

包装和存储

  • 干粉或者DMSO溶液置于带二维码的储存管中,或排列于96孔板/384孔板;
  • 蓝冰运输
获取筛选库化合物信息 (L5510)
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Antibacterial (257)
Autophagy (199)
Antibiotic (181)
Apoptosis (151)
Endogenous Metabolite (54)
5-HT Receptor (54)
Adrenergic Receptor (52)
DNA/RNA Synthesis (50)
Dopamine Receptor (45)
AChR (44)
COX (43)
Parasite (42)
HIV Protease (42)
Histamine Receptor (36)
Potassium Channel (30)
Topoisomerase (26)
Sodium Channel (26)
Ferroptosis (25)
Antifungal (24)
P450 (24)
Mitophagy (23)
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Calcium Channel (21)
Microtubule Associated (20)
RAAS (19)
VEGFR (19)
SARS-CoV (18)
PDGFR (18)
DNA Alkylator/Crosslinker (17)
Serotonin Transporter (17)
Reactive Oxygen Species (17)
Reverse Transcriptase (17)
GABA Receptor (16)
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Dehydrogenase (16)
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HDAC (14)
Norepinephrine (13)
PDE (13)
FLT (11)
ribosome (11)
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HSV (11)
ROS (11)
NF-κB (10)
MRP (10)
MAO (10)
Antifolate (9)
Virus Protease (9)
HCV Protease (9)
TNF (8)
Bcr-Abl (8)
Raf (8)
Proteasome (8)
Antifection (8)
HMG-CoA Reductase (8)
Estrogen Receptor/ERR (8)
Androgen Receptor (8)
ALK (8)
Opioid Receptor (8)
FGFR (8)
Src (8)
DNA Alkylation (8)
HBV (7)
Retinoid Receptor (7)
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CDK (7)
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化合物库信息示例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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