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3-TERT-BUTYL-4-HYDROXYANISOLE

Name: 3-TERT-BUTYL-4-HYDROXYANISOLE
Brand: TargetMol
SKU: T5367
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.65%

货号 T5367Cas号 121-00-6

别名 丁化羟基茴香醚

3-TERT-BUTYL-4-HYDROXYANISOLE 是一种抗氧化剂，通过水氯化生产。

3-TERT-BUTYL-4-HYDROXYANISOLE

一键复制产品信息

很棒

纯度: 99.65%

货号 T5367 别名 丁化羟基茴香醚Cas号 121-00-6

3-TERT-BUTYL-4-HYDROXYANISOLE 是一种抗氧化剂，通过水氯化生产。

规格	价格	库存	数量
2 g	¥ 108	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.65%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

3-TERT-BUTYL-4-HYDROXYANISOLE AI Summary

3-TERT-BUTYL-4-HYDROXYANISOLE exhibits a comprehensive range of bioactivities. It demonstrates strong antioxidant activity, as indicated by its 92.6% DPPH radical scavenging activity after 30 minutes at a concentration of 0.5 mM and an IC50 of 19000.0 nM in UV-visible spectrophotometry assays. It also shows potential antineoplastic effects by decreasing tumor incidence in benzo[alpha]pyrene-induced ICR/Ha mouse forestomachs with a tumor growth inhibition (TGI) of 50.0% at 5 mg/kg, although it is associated with some toxicity observed through decreased diet intake and body weight in mice. Moreover, 3-TERT-BUTYL-4-HYDROXYANISOLE exhibits antiviral activity against SARS-CoV-2, with notable inhibition of cytotoxicity in Caco-2 and VERO-6 cells at 10 µM concentrations as evidenced by high content imaging, and an inhibition rate of the 3CL-Pro protease by 12.26% at 20 µM in FRET-based assays. The compound also shows significant inhibition in various biochemical assays, including the inhibition of Aldehyde Dehydrogenase 1, Lipid Storage Modulators, Human alpha-Glucosidase, Histone Lysine Methyltransferase G9a, Marburg Virus entry, and the cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2). Additionally, it acts as an agonist of the antioxidant response element (ARE) signaling pathway and a small molecule activator of the human pregnane X receptor (PXR) signaling pathway. Enzyme assays reveal that 3-TERT-BUTYL-4-HYDROXYANISOLE displays specific activity with human recombinant UGT1A9 but not with UGT1A6, and it exhibits inhibitory activity against the human HDAC6 enzyme..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	3-tert-Butyl-p-hydroxyanisole is an antioxidant which is produced via water chlorination.
别名	丁化羟基茴香醚

化学信息

分子量	180.24
分子式	C₁₁H₁₆O₂
CAS No.	121-00-6
Smiles	COC1=CC(=C(O)C=C1)C(C)(C)C
密度	1.009 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (249.67 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5482 mL	27.7408 mL	55.4816 mL	277.4079 mL
5 mM	1.1096 mL	5.5482 mL	11.0963 mL	55.4816 mL
10 mM	0.5548 mL	2.7741 mL	5.5482 mL	27.7408 mL
20 mM	0.2774 mL	1.3870 mL	2.7741 mL	13.8704 mL
50 mM	0.1110 mL	0.5548 mL	1.1096 mL	5.5482 mL
100 mM	0.0555 mL	0.2774 mL	0.5548 mL	2.7741 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

3-TERT-BUTYL-4-HYDROXYANISOLE 3TERTBUTYL4HYDROXYANISOLE 3 TERT BUTYL 4 HYDROXYANISOLE

3-TERT-BUTYL-4-HYDROXYANISOLE

3-TERT-BUTYL-4-HYDROXYANISOLE