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SCF Protein, Mouse, Recombinant

SCF Protein, Mouse, Recombinant

产品编号 TMPJ-00166
别名: SCF, Hematopoietic growth factor KL, MGF, Steel factor, Mast cell growth factor, Stem cell factor, Kit ligand

Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.

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SCF Protein, Mouse, Recombinant
规格 价格/CNY 货期 数量
10 μg ¥ 870 现货
50 μg ¥ 1,960 5日内发货
500 μg ¥ 8,880 5日内发货
1 mg ¥ 13,900 5日内发货
夏季3重特惠
药物设计专题培训
Chloroquine限时半价
产品目录号及名称: SCF Protein, Mouse, Recombinant (TMPJ-00166)
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生物活性
技术参数
产品性质
生物活性 Measured by the dose-dependent stimulation of TF-1 cells. The ED50 for this effect is 4-12 ng/ml. (QC verified)

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产品描述 Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.
种属 Mouse
表达系统 E. coli
标签 Tag Free
蛋白编号 P20826
别名 SCF, Hematopoietic growth factor KL, MGF, Steel factor, Mast cell growth factor, Stem cell factor, Kit ligand
氨基酸序列 Lys26-Ala189
蛋白构建 Lys26-Ala189
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)

TargetMol

分子量 16 KDa (reducing condition)
内毒素 < 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.

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Keywords

SCF Protein, Mouse, Recombinant SCF Hematopoietic growth factor KL MGF Steel factor Mast cell growth factor Stem cell factor Kit ligand recombinant recombinant-proteins proteins protein

 

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