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SCF Protein, Mouse, Recombinant

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货号 TMPJ-00166

别名 Stem cell factor, Steel factor, SCF, MGF, Mast cell growth factor, Kit ligand, Hematopoietic growth factor KL

Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.

SCF Protein, Mouse, Recombinant
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SCF Protein, Human, Recombinant
SCF Protein, Mouse, Recombinant (His)
SCF Protein, Human, Recombinant (aa 1-189, His)
IGF1 LR3 Protein, Human, Recombinant
SCF Protein, Mouse, Recombinant (His), Biotinylated

SCF Protein, Mouse, Recombinant

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货号 TMPJ-00166 别名 Stem cell factor, Steel factor, SCF, MGF, Mast cell growth factor, Kit ligand, Hematopoietic growth factor KL

Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.

规格价格库存数量
5 μg
¥ 656
现货
10 μg
¥ 1,080
现货
20 μg
¥ 1,530
5日内发货
50 μg
¥ 2,430
5日内发货
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纯度: Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
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产品介绍

生物活性
产品描述
Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.
生物活性
Measured by the dose-dependent stimulation of TF-1 cells. The ED50 for this effect is 4-12 ng/ml. (QC verified)
SCF Protein, Mouse, Recombinant
研究背景
Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.
种属
Mouse
表达系统
E. coli
标签Tag Free
蛋白编号P20826
氨基酸序列Lys26-Ala189
蛋白构建Lys26-Ala189
蛋白纯度
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
SCF Protein, Mouse, Recombinant
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名Stem cell factor, Steel factor, SCF, MGF, Mast cell growth factor, Kit ligand, Hematopoietic growth factor KL
内毒素< 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
化学信息
分子量16 KDa (reducing condition)
颜色White
物理性状Lyophilized powder
储存&溶解度
运输方式In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
存储Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

计算器

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剂量转换

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技术支持

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