Name: Elipovimab
Brand: TargetMol
SKU: T77177
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 2,490

2-4周

5 mg

¥ 6,220

2-4周

10 mg

¥ 9,960

2-4周

生物活性

产品描述	Elipovimab is a humanized broadly neutralizing antibody (bNAb) targeting the V3 glycan supersite of the HIV-1 envelope glycoprotein gp120. As an Fc-optimized version of PGT121, it neutralizes viral particles and eliminates infected cells via antibody-dependent cellular cytotoxicity (ADCC). The antibody exhibits enhanced effector cell-mediated killing activity in the presence of TLR agonists.
体外活性	在利用 HIV 感染者 PBMCs 进行的离体实验中，Elipovimab (GS-9722) 对表达病毒包膜的细胞表现出强效的 ADCC 活性。利用 TLR7 或 TLR9 激动剂预处理 NK 细胞可显著提升 Elipovimab 介导的对自体 HIV 感染 CD4+ T 细胞的杀伤作用，并促进更高效的靶细胞清除 [1]。
别名	依帕韦单抗
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型	IgG1-ADLEEMLS

偶联与修饰

偶联	Unconjugated

抗原信息

靶点

HIV-1

化学信息

CAS No.

2101210-43-7

储存&溶解度

存储	Store at -20°C Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Elipovimab