Name: Olintatug
Brand: TargetMol
SKU: T9901A-365
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

待询

5 mg

待询

生物活性

产品描述	Olintatug (ADCT-901) is a highly specialized antibody-drug conjugate (ADC) targeting Kidney-Associated Antigen 1 (KAAG1). It comprises a humanized monoclonal antibody conjugated to a potent pyrrolobenzodiazepine (PBD) dimer cytotoxin via a cathepsin-cleavable linker. Olintatug specifically binds to KAAG1 on tumor cell surfaces, internalizes, and releases the PBD dimer, which induces lethal DNA interstrand cross-links, blocking cell division. It is investigated for KAAG1-expressing solid tumors, including ovarian and triple-negative breast cancers.
体外活性	在利用表达 c-Met 的胃癌细胞系开展的功能实验中，Olintatug 诱导了快速的受体内吞，并展示出皮摩尔级别的强效细胞毒活性 [1]。
体内活性	在胃癌和结直肠癌 PDX 模型中，通过全身给药方式给予 Olintatug，实验结果显示在不同 c-Met 表达水平的模型中均诱导了显著且持久的肿瘤退缩 [1]。
别名	奥林他妥, Anti-KAAG1 Antibody (ADCT-901), ADCT-901 Antibody, 3A4
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	Q9UBP8
靶点	KAAG1

化学信息

CAS No.

2851870-28-3

储存&溶解度

存储

Olintatug