Name: IL-7 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPJ-00059
Price: 693 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

5 μg

¥ 693

现货

10 μg

¥ 1,170

现货

20 μg

¥ 1,860

现货

50 μg

¥ 3,470

现货

100 μg

¥ 5,180

现货

200 μg

¥ 7,730

5日内发货

500 μg

¥ 13,200

5日内发货

生物活性

产品描述	Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction.
生物活性	1. Loaded Mouse IL-7RA-Fc on Protein A Biosensor, can bind Human IL-7-His with an affinity constant of 29.0 nM as determined in BLI assay. (Regularly tested) 2. Measured in a cell proliferation assay using PHA-activated human peripheral blood mononuclear cell (PBMC). The ED50 for this effect is 50-300 pg/ml. (QC verified)
研究背景	Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction.
种属	Human
表达系统	HEK293 Cells
标签	C-6xHis
蛋白编号	P13232
氨基酸序列	Asp26-His177
蛋白构建	Asp26-His177
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名	白细胞介素, 白介素, Interleukin-7, IL-7, IL7
内毒素	< 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.