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IL-7 Protein, Human, Recombinant (His)

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货号 TMPJ-00059

别名 白细胞介素, 白介素, Interleukin-7, IL-7, IL7

Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction.

IL-7 Protein, Human, Recombinant (His)
其他形式的 “IL-7 Protein, Human, Recombinant (His)”:
IL-7 Protein, Mouse, Recombinant (His)
IL-7 Protein, Bovine, Recombinant (His)
IL-7 Protein, Mouse, Recombinant
IL-7 Protein, Human, Recombinant

IL-7 Protein, Human, Recombinant (His)

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Rating icon 很棒
SPR兼容缓冲液
货号 TMPJ-00059 别名 白细胞介素, 白介素, Interleukin-7, IL-7, IL7

Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction.

规格价格库存数量
5 μg
¥ 693
现货
10 μg
¥ 1,170
现货
20 μg
¥ 1,860
现货
50 μg
¥ 3,470
现货
100 μg
¥ 5,180
现货
200 μg
¥ 7,730
5日内发货
500 μg
¥ 13,200
5日内发货
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纯度: Greater than 95% as determined by reducing SDS-PAGE.
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产品介绍

生物活性
产品描述
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction.
生物活性
1. Loaded Mouse IL-7RA-Fc on Protein A Biosensor, can bind Human IL-7-His with an affinity constant of 29.0 nM as determined in BLI assay. (Regularly tested) 2. Measured in a cell proliferation assay using PHA-activated human peripheral blood mononuclear cell (PBMC). The ED50 for this effect is 50-300 pg/ml. (QC verified)
IL-7 Protein, Human, Recombinant (His)IL-7 Protein, Human, Recombinant (His)
研究背景
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction.
种属
Human
表达系统
HEK293 Cells
标签C-6xHis
蛋白编号P13232
氨基酸序列Asp26-His177
蛋白构建Asp26-His177
蛋白纯度
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
IL-7 Protein, Human, Recombinant (His)
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4.
复溶方法Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名白细胞介素, 白介素, Interleukin-7, IL-7, IL7
内毒素< 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
化学信息
分子量19-30 KDa (reducing condition)
颜色White
物理性状Lyophilized powder
储存&溶解度
运输方式In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
存储Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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剂量转换

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技术支持

请阅读 重组蛋白用户指南 了解更多具体信息.

关键词

IL 7
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