CDK

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells.They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.

Cat. No.	Product Name	CAS No.	Purity
T2653	SB1317 化合物SB1317	1204918-72-8	98%
T2653	SB1317 是一种有效的细胞周期蛋白依赖性激酶 (CDKs)、Janus 激酶 2 (JAK2) 和 Fms 样酪氨酸激酶-3 (FLT3) 抑制剂。
T1947	BS-181 化合物BS-181	1092443-52-1	98%
T1947	BS181 是一种高度选择性的 CDK7 抑制剂，IC50为21 nM。它抑制CDK2、CDK5 和 CDK9 的IC50值分别为 880 nM、3000 nM 和 4200 nM 。它诱导细胞凋亡，有癌症研究相关的研究潜力。
TN1663	Ganoderic acid DM 灵芝酸 DM	173075-45-1	98%
TN1663	Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 ...
T17305	CDK8-IN-4 化合物 T17305	1613638-82-6	98%
T17305	CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).
TN4394	Kobophenol A 化合物 TN4394	124027-58-3	98%
TN4394	Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
T12617	(R)-CR8 trihydrochloride 化合物 T12617	1786438-30-9	98%
T12617	(R)-CR8 trihydrochloride 是一种有效的 CDK1/2/5/7/9 抑制剂。(R)-CR8 trihydrochloride 也可以作为一种分子胶降解剂来消耗细胞周期蛋白 K。
T5438	PROTAC CDK9 Degrader-1 化合物PROTAC CDK9 Degrader-1	2118356-96-8	98%
T5438	PROTAC CDK9 Degrader-1 是一种选择性 CDK9 降解剂，是由Cereblon 配体和CDK 配体相连的PROTAC。
T10737	CDK4/6-IN-3 化合物 T10737	2366237-37-6	98%
T10737	CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.
T16038	Men 10376 化合物 T16038	135306-85-3	98%
T16038	Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.
TN4263	Isoangustone A 化合物 TN4263	129280-34-8	98%
TN4263	Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
T11309	FMF-04-159-2 化合物 T11309	2364489-81-4	98%
T11309	FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. FMF-04-159-2 is a covalent CDK14 inhibitor.
T10739	CDK8/19-IN-1 化合物 T10739	1818427-07-4	98%
T10739	CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).
T15730	Ribociclib hydrochloride 瑞博西尼盐酸盐	1211443-80-9	98%
T15730	Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It is over 1,000-fold less potent against the cyclin B/CDK1...
T13425	(1S,3R,5R)-PIM447 dihydrochloride 化合物 T13425	T13425	98%
T13425	(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).
T11656	Indoramin D5 化合物 T11656	57165-41-0	98%
T11656	Indoramin D5 is a piperidine antiadrenergic agent. Indoramin D5 is deuterium labeled Indoramin.
T10172	5-Iodo-indirubin-3'-monoxime 5-碘靛红-3'-单肟	331467-03-9	98%
T10172	5-Iodo-indirubin-3'-monoxime 是一种 GSK-3β、CDK5/P25和CDK1/cyclin B 抑制剂，IC50值分别为 9、20 和 25 nM，与 ATP 竞争性地结合酶的催化位点。
T13309	Voruciclib hydrochloride 化合物 T13309	1000023-05-1	98%
T13309	Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).
TMA1743	Ergosterol peroxide 过氧麦角甾醇	2061-64-5	98%
TMA1743	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
TN3802	Dehydrodiconiferyl alcohol 化合物 TN3802	4263-87-0	98%
TN3802	Dehydrodiconiferyl alcohol shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. Dehydrodiconiferyl alcohol c...
T6139	A-674563 化合物A-674563	552325-73-2	98%
T6139	A674563 是一种口服有效，选择性的Akt1抑制剂，Ki=11 nM。