Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].
产品描述 | GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1]. |
体外活性 | GSK-3/CDK5/CDK2-IN-1 inhibits the phosphorylation of cdk5 peptide substrate phosphorylation, with an IC50 of less than about 50 μM[1]. |
别名 | GSK-3/CDK5/CDK2-IN-1 |
分子量 | 362.433 |
分子式 | C21H22N4O2 |
CAS No. | 395074-72-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (275.92 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7591 mL | 13.7957 mL | 27.5913 mL | 68.9783 mL |
5 mM | 0.5518 mL | 2.7591 mL | 5.5183 mL | 13.7957 mL | |
10 mM | 0.2759 mL | 1.3796 mL | 2.7591 mL | 6.8978 mL | |
20 mM | 0.138 mL | 0.6898 mL | 1.3796 mL | 3.4489 mL | |
50 mM | 0.0552 mL | 0.2759 mL | 0.5518 mL | 1.3796 mL | |
100 mM | 0.0276 mL | 0.138 mL | 0.2759 mL | 0.6898 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
GSK-3/CDK5/CDK2-IN-1 395074-72-3 GSK3/CDK5/CDK2IN1 GSK-3/CDK-5/CDK2-IN-1 GSK 3/CDK5/CDK2 IN 1 Inhibitor inhibitor inhibit