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Search Results for "MES"

15

抑制剂 & 化合物

12

化合物库

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Cat. No. Product Name
L2192 抗胰腺癌化合物库

2267 compounds
2267种与胰腺癌相关的化合物,可以用于高通量和高内涵筛选;
L1610 FDA 上市激酶抑制剂库

280 compounds
TargetMol FDA上市激酶库包含280个具有明确激酶抑制活性的上市药物
L1600 激酶抑制剂库

2230 compounds
2230种激酶抑制剂的独特集合,用于特定靶向激酶,可用于高通量筛选和高内涵筛选;
L5400 抗心血管疾病化合物库

1428 compounds
1428种心血管疾病相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选;
DP9200 DGK抑制剂库

12000 compounds
包含12000种类药化合物,源自知名品牌Chemdiv,从160万小分子中百里挑一;
L1110 微管靶向化合物库

80 compounds
80种靶向微管的分子集合,用于高通量筛选和高内涵筛选;
L8400 血液病分子库

524 compounds
524种造血系统疾病相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选;
L6210 藏药化合物库

754 compounds
754种藏药来源的天然产物分子集合,可以用于高通量和高内涵筛选;
CL0091 MEK inhibitor kit

CL0089 c-Met/HGFR inhibitor kit

CL0109 Ras inhibitor kit

CL0085 HSP inhibitor kit

化合物库

抗胰腺癌化合物库
L2192
Compounds: 2267
FDA 上市激酶抑制剂库
L1610
Compounds: 280
激酶抑制剂库
L1600
Compounds: 2230
抗心血管疾病化合物库
L5400
Compounds: 1428
DGK抑制剂库
DP9200
Compounds: 12000
微管靶向化合物库
L1110
Compounds: 80
血液病分子库
L8400
Compounds: 524
藏药化合物库
L6210
Compounds: 754
MEK inhibitor kit
CL0091
Compounds: 0
c-Met/HGFR inhibitor kit
CL0089
Compounds: 0
Ras inhibitor kit
CL0109
Compounds: 0
HSP inhibitor kit
CL0085
Compounds: 0
Cat. No. Product Name Target Signaling Pathways
T61827 RJ-34

RJ-34 是一种 Aristolactam 类似物,对一系列癌细胞系具有强大的抗肿瘤活性, GI50值在亚纳摩尔范围内 (对 A431、MES-SA、MES-SA/DX5、HCT-15 和 HCT-15/CLO2细胞的 GI50小于 0.1 nM)。
T37950 2-(Isopentylamino)naphthalene-1,4-dione

2-(Isopentylamino)naphthalene-1,4-dione is a vitamin K analog.1It inhibits spasms induced by pentylenetetrazole and tonic hindlimb extension induced by maximal electroshock (MES) in mice (ED50s = 349.2 and 108.1 mg/kg, respectively). It also protects mice against seizures in the 6 Hz psychomotor seizure test (ED50s = 152.7 and 263.7 mg/kg at stimulus intensities of 32 and 44 mA, respectively). 1.Li, X., Himes, R.A., Prosser, L.C., et al.Discovery of the first vitamin K analogue as a potential tr...
T61745 HCAI/II-IN-6

hCAI/II-IN-6 是一种具有口服活性的human carbonic anhydrase(CA) 抑制剂。hCAI/II-IN-6 选择性地抑制 hCA II 和 hCA VII,对 hCA I,hCA II,hCA VII 和 hCA XII 的Ki值分别为 220,4.9,6.5 和 >50000 nM。hCAI/II-IN-6 在体内显示抗惊厥活性和抗最大电击 (MES) 活性。hCAI/II-IN-6 可以用于癫痫的研究。
T37847 Zonisamide-13C2,15N

Zonisamide-13C2,15N

Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...
T40545 MES

4-Morpholineethanesulfonic acid; 2-Morpholinoethanesulphonic acid

Others Others
MES (2-Morpholinoethanesulphonic acid) 是一种两性离子缓冲液,在 pH 值 5.5-7.7 范围内有效。MES 作为一种 Good's 缓冲液,广泛应用于植物培养基、试剂溶液和生理实验中调节 pH 值。
T40819 MES sodium salt

2-Morpholinoethanesulphonic acid sodium salt

MES (2-Morpholinoethanesulphonic acid) sodium salt, a zwitterionic buffer, is effective in the pH range of 5.5-7.7. MES sodium salt, as one of the Good’s buffers, is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments.
T65287 MES monohydrate

T65286 MES hemisodium salt

T23581 2-Methylthioadenosine diphosphate trisodium

2MeSADP; 2 Methylthio ADP; 2-Methylthio-ADP; 2-MeS-ADP; 2 MeS ADP

2-MeS-ADP is a purinergic agonist that acts by displaying selectivity for P2Y1, P2Y12, and P2Y13 receptors and inhibiting cAMP accumulation.
T11106 DSP-0565

Others Others
DSP-0565 在包括 scPTZ、6 Hz、MES 和杏仁核点燃在内的各种模型中表现出抗惊厥活性和良好的安全裕度。 DSP-0565 可用于作为广谱抗癫痫药物的研究。
T70896 PF05020182

PF05020182 is novel potent and selective Kv7.2/4 potassium channel opener. PF-05020182 (2) significantly inhibits convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochemical properties, in vitro and in vivo activities of PF-05020182 support further development as an adjunctive treatment of refractory epilepsy. Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in cont...
T68918 Phenytoin-d10

Phenytoin-d10 is intended for use as an internal standard for the quantification of phenytoin by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin. Phenytoin is formed from fosphenytoin by tissue phosphatases. It inhibits neuronal voltage-gated sodium channels in a voltage-dependent manner. Phenytoin reduces the neuronal firing frequency and decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat corticostriatal...
T24975 2MeSAMP

2-MeS-AMP bis-sodium; 2MeSAMP bis-sodium; 2 MeS AMP bis-sodium

2MeSAMP is a P2Y(12) antagonist that works by inhibiting platelet activation through a P2Y(12)/G(i)-dependent mechanism.
T7938 Quinidine

奎尼丁; 奎宁树

Parasite Microbiology/Virology
Quinidine 是一种抗心律失常剂,也是 K+通道的有效阻断剂,其IC50值为 19.9 μM。它是一种选择性细胞色素 P450db 的有效抑制剂,也可研究疟疾。
T8125 Quinidine sulfate dihydrate

β-quinine Sodium; 硫酸奎尼宁; Quinidine sulfate; 硫酸奎尼丁二水合物; Pitayine Sodium; Chinidin Sodium

P450 Metabolism
Quinidine sulfate 是抗心律失常剂,能够阻断 K+通道(IC50:19.9 μM)。它是细胞色素 P450db 的选择性抑制剂,可用于研究疟疾。

化合物

RJ-34
T61827
synonym:
Target:
2-(Isopentylamino)naphthalene-1,4-dione
T37950
synonym:
Target:
hCAI/II-IN-6
T61745
synonym:
Target:
Zonisamide-13C2,15N
T37847
synonym: Zonisamide-13C2,15N
Target:
MES
T40545
synonym: 4-Morpholineethanesulfonic acid; 2-Morpholinoethanesulphonic acid
Target: Others
MES sodium salt
T40819
synonym: 2-Morpholinoethanesulphonic acid sodium salt
Target:
MES monohydrate
T65287
synonym:
Target:
MES hemisodium salt
T65286
synonym:
Target:
2-Methylthioadenosine diphosphate trisodium
T23581
synonym: 2MeSADP; 2 Methylthio ADP; 2-Methylthio-ADP; 2-MeS-ADP; 2 MeS ADP
Target:
DSP-0565
T11106
synonym:
Target: Others
PF05020182
T70896
synonym:
Target:
Phenytoin-d10
T68918
synonym:
Target:
2MeSAMP
T24975
synonym: 2-MeS-AMP bis-sodium; 2MeSAMP bis-sodium; 2 MeS AMP bis-sodium
Target:
Quinidine
T7938
synonym: 奎尼丁; 奎宁树
Target: Parasite
Quinidine sulfate dihydrate
T8125
synonym: β-quinine Sodium; 硫酸奎尼宁; Quinidine sulfate; 硫酸奎尼丁二水合物; Pitayine Sodium; Chinidin Sodium
Target: P450