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| Cat. No. | Product Name | ||
|---|---|---|---|
| L2192 | 抗胰腺癌化合物库 | 2267 compounds | |
| 2267种与胰腺癌相关的化合物，可以用于高通量和高内涵筛选； | |||
| L1610 | FDA 上市激酶抑制剂库 | 280 compounds | |
| TargetMol FDA上市激酶库包含280个具有明确激酶抑制活性的上市药物 | |||
| L1600 | 激酶抑制剂库 | 2230 compounds | |
| 2230种激酶抑制剂的独特集合，用于特定靶向激酶，可用于高通量筛选和高内涵筛选； | |||
| L5400 | 抗心血管疾病化合物库 | 1428 compounds | |
| 1428种心血管疾病相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选； | |||
| DP9200 | DGK抑制剂库 | 12000 compounds | |
| 包含12000种类药化合物，源自知名品牌Chemdiv，从160万小分子中百里挑一； | |||
| L1110 | 微管靶向化合物库 | 80 compounds | |
| 80种靶向微管的分子集合，用于高通量筛选和高内涵筛选； | |||
| L8400 | 血液病分子库 | 524 compounds | |
| 524种造血系统疾病相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选； | |||
| L6210 | 藏药化合物库 | 754 compounds | |
| 754种藏药来源的天然产物分子集合，可以用于高通量和高内涵筛选； | |||
| CL0091 | MEK inhibitor kit | ||
| CL0089 | c-Met/HGFR inhibitor kit | ||
| CL0109 | Ras inhibitor kit | ||
| CL0085 | HSP inhibitor kit | ||
| Cat. No. | Product Name | Target | Signaling Pathways |
|---|---|---|---|
| T61827 | RJ-34 | ||
| RJ-34 是一种 Aristolactam 类似物，对一系列癌细胞系具有强大的抗肿瘤活性, GI50值在亚纳摩尔范围内 (对 A431、MES-SA、MES-SA/DX5、HCT-15 和 HCT-15/CLO2细胞的 GI50小于 0.1 nM)。 | |||
| T37950 | 2-(Isopentylamino)naphthalene-1,4-dione | ||
| 2-(Isopentylamino)naphthalene-1,4-dione is a vitamin K analog.1It inhibits spasms induced by pentylenetetrazole and tonic hindlimb extension induced by maximal electroshock (MES) in mice (ED50s = 349.2 and 108.1 mg/kg, respectively). It also protects mice against seizures in the 6 Hz psychomotor seizure test (ED50s = 152.7 and 263.7 mg/kg at stimulus intensities of 32 and 44 mA, respectively). 1.Li, X., Himes, R.A., Prosser, L.C., et al.Discovery of the first vitamin K analogue as a potential tr... | |||
| T61745 | HCAI/II-IN-6 | ||
| hCAI/II-IN-6 是一种具有口服活性的human carbonic anhydrase(CA) 抑制剂。hCAI/II-IN-6 选择性地抑制 hCA II 和 hCA VII，对 hCA I，hCA II，hCA VII 和 hCA XII 的Ki值分别为 220，4.9，6.5 和 ＞50000 nM。hCAI/II-IN-6 在体内显示抗惊厥活性和抗最大电击 (MES) 活性。hCAI/II-IN-6 可以用于癫痫的研究。 | |||
| T37847 |
Zonisamide-13C2,15N
Zonisamide-13C2,15N |
||
| Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium... | |||
| T40545 |
MES
4-Morpholineethanesulfonic acid; 2-Morpholinoethanesulphonic acid |
Others | Others |
| MES (2-Morpholinoethanesulphonic acid) 是一种两性离子缓冲液，在 pH 值 5.5-7.7 范围内有效。MES 作为一种 Good's 缓冲液，广泛应用于植物培养基、试剂溶液和生理实验中调节 pH 值。 | |||
| T40819 |
MES sodium salt
2-Morpholinoethanesulphonic acid sodium salt |
||
| MES (2-Morpholinoethanesulphonic acid) sodium salt, a zwitterionic buffer, is effective in the pH range of 5.5-7.7. MES sodium salt, as one of the Good’s buffers, is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments. | |||
| T65287 | MES monohydrate | ||
| T65286 | MES hemisodium salt | ||
| T23581 |
2-Methylthioadenosine diphosphate trisodium
2MeSADP; 2 Methylthio ADP; 2-Methylthio-ADP; 2-MeS-ADP; 2 MeS ADP |
||
| 2-MeS-ADP is a purinergic agonist that acts by displaying selectivity for P2Y1, P2Y12, and P2Y13 receptors and inhibiting cAMP accumulation. | |||
| T11106 | DSP-0565 | Others | Others |
| DSP-0565 在包括 scPTZ、6 Hz、MES 和杏仁核点燃在内的各种模型中表现出抗惊厥活性和良好的安全裕度。 DSP-0565 可用于作为广谱抗癫痫药物的研究。 | |||
| T70896 | PF05020182 | ||
| PF05020182 is novel potent and selective Kv7.2/4 potassium channel opener. PF-05020182 (2) significantly inhibits convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochemical properties, in vitro and in vivo activities of PF-05020182 support further development as an adjunctive treatment of refractory epilepsy. Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in cont... | |||
| T68918 | Phenytoin-d10 | ||
| Phenytoin-d10 is intended for use as an internal standard for the quantification of phenytoin by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin. Phenytoin is formed from fosphenytoin by tissue phosphatases. It inhibits neuronal voltage-gated sodium channels in a voltage-dependent manner. Phenytoin reduces the neuronal firing frequency and decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat corticostriatal... | |||
| T24975 |
2MeSAMP
2-MeS-AMP bis-sodium; 2MeSAMP bis-sodium; 2 MeS AMP bis-sodium |
||
| 2MeSAMP is a P2Y(12) antagonist that works by inhibiting platelet activation through a P2Y(12)/G(i)-dependent mechanism. | |||
| T7938 |
Quinidine
奎尼丁; 奎宁树 |
Parasite | Microbiology/Virology |
| Quinidine 是一种抗心律失常剂，也是 K+通道的有效阻断剂，其IC50值为 19.9 μM。它是一种选择性细胞色素 P450db 的有效抑制剂，也可研究疟疾。 | |||
| T8125 |
Quinidine sulfate dihydrate
β-quinine Sodium; 硫酸奎尼宁; Quinidine sulfate; 硫酸奎尼丁二水合物; Pitayine Sodium; Chinidin Sodium |
P450 | Metabolism |
| Quinidine sulfate 是抗心律失常剂，能够阻断 K+通道(IC50:19.9 μM)。它是细胞色素 P450db 的选择性抑制剂，可用于研究疟疾。 | |||
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