Azamulin

Name: Azamulin
Brand: TargetMol
SKU: T37183
Rating: 4.5 (1 reviews)

还可以

产品编号 T37183Cas号 76530-44-4

别名 Antibiotic TDM 85-530

Azamulin is a selective, irreversible inhibitor of cytochrome P450 (CYP) 3A isoforms (IC50 values range from 26 to 240 nM for CYP3A4 and CYP3A4/5 from different sources). [1] It is at least 50-fold less potent against CYP2J2 and 100-fold less effective against all other CYP isoforms. [1] Azamulin potently blocks the hydroxylation of testosterone and midazolam by CYP3A4.[2]

Azamulin

还可以

产品编号 T37183 别名 Antibiotic TDM 85-530Cas号 76530-44-4

规格	价格	库存	数量
100 mg	待询	6-8周

大包装 & 定制

该分子属于定制产品。TargetMol拥有优秀的合成团队，经验和能力，可以为您提供高性价比的产品。但由于客观因素，研发中会存在小概率合成不成功的情况，还请理解，如您有任何问题，欢迎咨询，我们将竭诚为您服务。

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产品介绍

生物活性

产品描述	Azamulin is a selective, irreversible inhibitor of cytochrome P450 (CYP) 3A isoforms (IC50 values range from 26 to 240 nM for CYP3A4 and CYP3A4/5 from different sources). [1] It is at least 50-fold less potent against CYP2J2 and 100-fold less effective against all other CYP isoforms. [1] Azamulin potently blocks the hydroxylation of testosterone and midazolam by CYP3A4.[2]
靶点活性	CYP3A:0.03-0.24 μM
别名	Antibiotic TDM 85-530

化学信息

分子量	478.65
分子式	C₂₄H₃₈N₄O₄S
CAS No.	76530-44-4

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 20 mg/mL (41.78 mM), Sonication is recommended.

DMF: 20 mg/mL (41.78 mM), Sonication is recommended.

Ethanol: 20 mg/mL (41.78 mM), Sonication is recommended.

溶液配制表

DMSO/DMF/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.0892 mL	10.4460 mL	20.8921 mL	104.4605 mL
5 mM	0.4178 mL	2.0892 mL	4.1784 mL	20.8921 mL
10 mM	0.2089 mL	1.0446 mL	2.0892 mL	10.4460 mL
20 mM	0.1045 mL	0.5223 mL	1.0446 mL	5.2230 mL