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COPS2 Protein, Human, Recombinant (His)

COPS2 Protein, Human, Recombinant (His)

产品编号 TMPH-01137
别名: csn2, cops2, COP9 signalosome complex subunit 2, Signalosome subunit 2

COPS2 Protein, Human, Recombinant (His) is expressed in Yeast.

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COPS2 Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
20 μg ¥ 2,170 20日内发货
100 μg ¥ 3,970 20日内发货
500 μg ¥ 11,300 20日内发货
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产品目录号及名称: COPS2 Protein, Human, Recombinant (His) (TMPH-01137)
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生物活性
技术参数
产品性质
产品描述 COPS2 Protein, Human, Recombinant (His) is expressed in Yeast.
种属 Human
表达系统 P. pastoris (Yeast)
标签 N-6xHis
蛋白编号 P61201
别名 csn2, cops2, COP9 signalosome complex subunit 2, Signalosome subunit 2
氨基酸序列 MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYISTSKQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA
蛋白构建 1-443 aa
蛋白纯度 > 85% as determined by SDS-PAGE.
分子量 53.6 kDa (predicted)
缓冲液 Tris-based buffer, 50% glycerol
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

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Keywords

COPS2 Protein, Human, Recombinant (His) csn2 cops2 COP9 signalosome complex subunit 2 Signalosome subunit 2 recombinant recombinant-proteins proteins protein

 

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