Tinoridine

Name: Tinoridine
Brand: TargetMol
SKU: T50001
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.08%

货号 T50001Cas号 24237-54-5

别名 替诺立定, ethyl 2-amino-6-benzyl-4H,5H,6H,7H-thieno[2,3-c]pyridine-3-carboxylate

Tinoridine 通过抑制环氧合酶-2（COX-2）的产生来发挥作用，具有抗炎、抗过敏和抗凝血等活性。

Tinoridine

一键复制产品信息

很棒

纯度: 99.08%

货号 T50001 别名 替诺立定, ethyl 2-amino-6-benzyl-4H,5H,6H,7H-thieno[2,3-c]pyridine-3-carboxylateCas号 24237-54-5

Tinoridine 通过抑制环氧合酶-2（COX-2）的产生来发挥作用，具有抗炎、抗过敏和抗凝血等活性。

规格	价格	库存
100 mg	¥ 137	现货
200 mg	¥ 193	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

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纯度: 99.08%

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COA HNMR LCMS 产品操作手册

产品介绍

Tinoridine AI Summary

Tinoridine exhibits allosteric modulatory activity at the human adenosine A1 receptor with an EC50 of 10300.0 nM, causing a half-maximal allosteric effect on [125I]-ABA dissociation from the receptor-G protein ternary complex. It retains 44.9% activity at a concentration of 50 µM after 10 minutes of radioligand dissociation. Additionally, Tinoridine displays a diverse range of bioactivities, including inhibition of Menin-MLL interaction, modulation of Lamin A splicing, inhibition of Cruzain and Tau fibril formation, and activity against several other targets such as Sfp phosphopantetheinyl transferase, Fructose-1,6-bisphosphate aldolase, VHR1, Histone lysine methyltransferase G9a, 15-hLO-2, vitamin D receptor, and malarial parasite plastid. It also blocks entry of pathogens like Ebola and Lassa viruses, induces DNA re-replication in normal breast cells, and inhibits DNA repair enzyme TDP1. The compound demonstrates a high clearance rate of 71.2 mL.min-1.g-1 in human liver microsomes at 1 µM, suggesting efficient liver metabolism. It exhibits moderate liver toxicity, with some instances of severe hepatitis, chronic liver disease, and cirrhosis, but no evidence of cytolytic or cholestatic liver toxicity, granulomatous hepatitis, or vascular disease association. Despite its broad bioactivity, Tinoridine shows weak antiviral activity against SARS-CoV-2, with an IC50 value greater than 20000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Tinoridine is a quinoline derivative analog that acts by inhibiting the production of cyclooxygenase-2 (COX-2). It has anti-inflammatory, anti-allergic and anticoagulant activities.
靶点活性	CYP2D6 (human):0.0098µM
别名	替诺立定, ethyl 2-amino-6-benzyl-4H,5H,6H,7H-thieno[2,3-c]pyridine-3-carboxylate

化学信息

分子量	316.42
分子式	C₁₇H₂₀N₂O₂S
CAS No.	24237-54-5
Smiles	CCOC(=O)c1c(N)sc2CN(Cc3ccccc3)CCc12
密度	1.256 g/cm3
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (158.02 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1604 mL	15.8018 mL	31.6036 mL	158.0178 mL
5 mM	0.6321 mL	3.1604 mL	6.3207 mL	31.6036 mL
10 mM	0.3160 mL	1.5802 mL	3.1604 mL	15.8018 mL
20 mM	0.1580 mL	0.7901 mL	1.5802 mL	7.9009 mL
50 mM	0.0632 mL	0.3160 mL	0.6321 mL	3.1604 mL
100 mM	0.0316 mL	0.1580 mL	0.3160 mL	1.5802 mL