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Clomesone

Name: Clomesone
Brand: TargetMol
SKU: T50086
Price: 443 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T50086Cas号 88343-72-0 一键复制产品信息纯度: 99.76%

很棒

Clomesone 是一种合成的非甾体药物，可用作分子结构单元。它是一种常用于治疗女性不孕的药物，通过阻断大脑中雌激素的作用发挥作用，已被证明对患有多囊卵巢综合征和其他不孕问题的女性有效诱导排卵。

Clomesone

一键复制产品信息

很棒

纯度: 99.76%

货号 T50086Cas号 88343-72-0

规格	价格	库存
1 mg	¥ 443	现货
5 mg	¥ 1,030	现货
10 mg	¥ 1,530	现货
25 mg	¥ 2,430	现货
50 mg	¥ 3,310	现货
100 mg	¥ 4,420	现货
1 mL x 10 mM (in DMSO)	¥ 852	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.76%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

Clomesone AI Summary

Clomesone exhibits a range of bioactivities, including dose-dependent effects on mortality rates, weight changes, and survival times in experimental settings. It has a half-life of 9.4 hours after NBP alkylation and demonstrates in vitro growth inhibition against L1210 murine leukemia cells with an IC50 value of 3000.0 nM. The compound shows varying potencies across different human tumor cell lines, with GI50 values ranging from 10,000 nM to over 900,000 nM for cancer types including breast, renal, lung, leukemia, melanoma, ovarian, prostate, colon, and central nervous system cancers. It also exhibits antiviral activity against SARS-CoV-2; it inhibits cytotoxicity in Caco-2 cells and VERO-6 cells at a 10 µM concentration, with notable inhibition percentages. Additionally, Clomesone shows partial inhibition (2.953%) of SARS-CoV-2 3CL-Pro protease at 20 µM. This compound also inhibits human HDAC6 activity in enzymatic assays, with an inhibition rate of 9.47% using a commercial peptide substrate and -12.59% using a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

Clomesone is a synthetic non-steroidal drug that can be used as a molecular structural unit. It is a drug commonly used to treat female infertility and works by blocking the action of estrogen in the brain. It has been shown to be effective in inducing ovulation in women suffering from polycystic ovary syndrome and other infertility problems.

化学信息

分子量	236.69
分子式	C₄H₉ClO₅S₂
CAS No.	88343-72-0
Smiles	C(S(OCCCl)(=O)=O)S(C)(=O)=O
密度	1.31g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 55 mg/mL (232.37 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2249 mL	21.1247 mL	42.2494 mL	211.2468 mL
5 mM	0.8450 mL	4.2249 mL	8.4499 mL	42.2494 mL
10 mM	0.4225 mL	2.1125 mL	4.2249 mL	21.1247 mL
20 mM	0.2112 mL	1.0562 mL	2.1125 mL	10.5623 mL
50 mM	0.0845 mL	0.4225 mL	0.8450 mL	4.2249 mL
100 mM	0.0422 mL	0.2112 mL	0.4225 mL	2.1125 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。