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Anti-JAB1 Antibody (6A480)

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Anti-JAB1 Antibody (6A480)
产品编号 TMAC-02257
别名 Signalosome subunit 5, SGN5, SGN 5, MOV34 family, 38-KD member, MOV34, MOV 34, MGC3149, Jun activation domain-binding protein 1, Jun activation domain binding protein 1, Jun activation domain binding protein, JAB 1, CSN5_HUMAN, CSN5, CSN 5, cops5, COPS 5, Cop9 subunit 5, COP9 signalosome subunit 5, COP9 signalosome complex subunit 5, COP9 constitutive photomorphogenic homolog subunit 5, COP9 (constitutive photomorphogenic) homolog subunit 5, 38 kDa Mov34 homolog

Anti-JAB1 Antibody (6A480) 是一种 Rabbit 抗体,靶向 JAB1。Anti-JAB1 Antibody (6A480) 可用于 WB,ICC,IF,IHC,IP。

Anti-JAB1 Antibody (6A480)

Anti-JAB1 Antibody (6A480)

Rating icon 还可以
Anti-JAB1 Antibody (6A480)
产品编号 TMAC-02257 别名 Signalosome subunit 5, SGN5, SGN 5, MOV34 family, 38-KD member, MOV34, MOV 34, MGC3149, Jun activation domain-binding protein 1, Jun activation domain binding protein 1, Jun activation domain binding protein, JAB 1, CSN5_HUMAN, CSN5, CSN 5, cops5, COPS 5, Cop9 subunit 5, COP9 signalosome subunit 5, COP9 signalosome complex subunit 5, COP9 constitutive photomorphogenic homolog subunit 5, COP9 (constitutive photomorphogenic) homolog subunit 5, 38 kDa Mov34 homolog

Anti-JAB1 Antibody (6A480) 是一种 Rabbit 抗体,靶向 JAB1。Anti-JAB1 Antibody (6A480) 可用于 WB,ICC,IF,IHC,IP。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-JAB1 Antibody (6A480) is a Rabbit antibody targeting JAB1. Anti-JAB1 Antibody (6A480) can be used in WB,ICC,IF,IHC,IP.
别名Signalosome subunit 5, SGN5, SGN 5, MOV34 family, 38-KD member, MOV34, MOV 34, MGC3149, Jun activation domain-binding protein 1, Jun activation domain binding protein 1, Jun activation domain binding protein, JAB 1, CSN5_HUMAN, CSN5, CSN 5, cops5, COPS 5, Cop9 subunit 5, COP9 signalosome subunit 5, COP9 signalosome complex subunit 5, COP9 constitutive photomorphogenic homolog subunit 5, COP9 (constitutive photomorphogenic) homolog subunit 5, 38 kDa Mov34 homolog
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of JAB1 on different lysate using anti-JAB1 antibody at 1/500 dilution. Positive control: Lane 1: Mouse testis tissue, Lane 2: PC-3M, Lane 3: A549
2. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-JAB1 antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-JAB1 antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-JAB1 antibody. Counter stained with hematoxylin.
5. ICC staining JAB1 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
6. ICC staining JAB1 in PC-3M cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
7. ICC staining JAB1 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
应用
推荐剂量
WB: 1:500; IHC: 1:50-200; ICC: 1:100-500
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Genes belonging to the Jun and Fos oncogene families encode nuclear proteins that are found to be associated with a number of transcriptional complexes. The c-Jun protein is a major component of the transcription factor AP-1, originally shown to mediate phorbol ester tumor promoter (TPA)-induced expression of responsive genes through the TPA-response element (TRE). The Jun proteins form homo- and heterodimers which bind the TRE, but the Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. The coactivator of Jun, designated JAB1 (for Jun-activation domain-binding protein), interacts with c-Jun and Jun D, but not with Jun B or v-Jun. This interaction enhances the transactivating ability of Jun proteins by stabilizing their binding to the TRE. The gene encoding JAB1 maps to human chromosome 8q12.3.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
化学信息
分子量Theoretical: 37, 100 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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