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5-HT Receptor

5-HT Receptor

5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission.
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Cat. No. Product Name CAS No. Purity Chemical Structure
T0039 Dapoxetine
达波西汀
119356-77-3 98%
Dapoxetine 是一种选择性5-羟色胺再摄取抑制剂,用于治疗早泄。
T3086 Mesoridazine Besylate
苯磺酸美索达嗪
32672-69-8 98%
Mesoridazine Besylate 是一种哌啶类精神安定药,属于称为吩噻嗪类的药物,用于治疗精神分裂症。它是硫利达嗪的代谢物。
T62269 F 14679
化合物F 14679
208109-38-0 98%
F 14679 是一种有效的5-HT1A 激动剂(pKi=10.23),具有 Ca2t 的最大反应与5-HT 相似。
T28414 Piclozotan
化合物Piclozotan
182415-09-4 98%
Piclozotan (anhydrous) 是一种 5-HT1A 受体激动剂,在短暂的大脑中动脉闭塞(t-MCAO)模型中表现出显着的神经保护活性,可以改善晚期帕金森病患者的运动并发症。
T4348 Syk Inhibitor II
化合物Syk Inhibitor II
726695-51-8 98%
Syk Inhibitor II 是一种可渗透细胞、具有 ATP 竞争性的嘧啶-甲酰胺化合物,可选择性且可逆地抑制 Syk,IC50为 41 nM。
T8702 SKF-83566
化合物SKF-83566
99295-33-7 98%
SKF-83566 是一种具有血脑渗透性和口服活性的 D1 样多巴胺受体拮抗剂和一种较弱的竞争性 5-HT2 受体拮抗剂,Ki 为 11 nM。它是竞争性多巴胺转运蛋白抑制剂,可用于研究帕金森氏症和对尼古丁渴望的缓解的相关研究。
T1769 Pardoprunox
帕多芦诺
269718-84-5 98%
Pardoprunox 是多巴胺受体D2、D3部分激动剂和5-HT1A 激动剂,pEC50分别为 8、9.2 和 6.3。
TN1415 Auraptenol
化合物Auraptenol
1221-43-8 98%
Auraptenol possesses robust antidepressant-like efficacy in mice.
T15100 Desmethyl cariprazine
化合物 T15100
839712-15-1 98%
Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (K...
T17095 TIK-301
化合物 T17095
118702-11-7 98%
TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM,...
T11949 Masupirdine mesylate
化合物 T11949
1791396-46-7 98%
Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's d...
T19381 Isobutyryl-L-carnitine
化合物 T19381
25518-49-4 98%
Isobutyryl-L-carnitine is a member of the class of compounds known as acylcarnitines. Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases.
T13339 Wf-516
化合物 T13339
310392-94-0 98%
Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant activit...
TN4713 Onitisin
化合物 TN4713
53823-03-3 98%
Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum.
T10380 AS19
化合物 T10380
1000578-26-6 98%
AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Ki...
T15026 Cyamemazine
化合物 T15026
3546-03-0 98%
Cyamemazine, contains the phenothiazine chromophore, is a neuroleptic agent used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki: 12 nM), 5-HT2A (Ki: 1.5 nM)...
T13021 Sulamserod
化合物 T13021
219757-90-1 98%
Sulamserod is an antagonist of 5-HT4 receptor, has antiarrhythmic activities.
T16433 Pancopride
化合物 T16433
121650-80-4 98%
Pancopride is a new effective and selective antagonist of the 5-HT3 receptor.
T12262L NPS ALX Compound 4a dihydrochloride
化合物 T12262L
1781934-44-8 98%
NPS ALX Compound 4a dihydrochloride is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM)
T10114 3-Hydroxy agomelatine
化合物 T10114
166526-99-4 98%
3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM).
Dapoxetine
T0039
Dapoxetine 是一种选择性5-羟色胺再摄取抑制剂,用于治疗早泄。
Mesoridazine Besylate
T3086
Mesoridazine Besylate 是一种哌啶类精神安定药,属于称为吩噻嗪类的药物,用于治疗精神分裂症。它是硫利达嗪的代谢物。
F 14679
T62269
F 14679 是一种有效的5-HT1A 激动剂(pKi=10.23),具有 Ca2t 的最大反应与5-HT 相似。
Piclozotan
T28414
Piclozotan (anhydrous) 是一种 5-HT1A 受体激动剂,在短暂的大脑中动脉闭塞(t-MCAO)模型中表现出显着的神经保护活性,可以改善晚期帕金森病患者的运动并发症。
Syk Inhibitor II
T4348
Syk Inhibitor II 是一种可渗透细胞、具有 ATP 竞争性的嘧啶-甲酰胺化合物,可选择性且可逆地抑制 Syk,IC50为 41 nM。
SKF-83566
T8702
SKF-83566 是一种具有血脑渗透性和口服活性的 D1 样多巴胺受体拮抗剂和一种较弱的竞争性 5-HT2 受体拮抗剂,Ki 为 11 nM。它是竞争性多巴胺转运蛋白抑制剂,可用于研究帕金森氏症和对尼古丁渴望的缓解的相关研究。
Pardoprunox
T1769
Pardoprunox 是多巴胺受体D2、D3部分激动剂和5-HT1A 激动剂,pEC50分别为 8、9.2 和 6.3。
Auraptenol
TN1415
Auraptenol possesses robust antidepressant-like efficacy in mice.
Desmethyl cariprazine
T15100
Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (K...
TIK-301
T17095
TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM,...
Masupirdine mesylate
T11949
Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's d...
Isobutyryl-L-carnitine
T19381
Isobutyryl-L-carnitine is a member of the class of compounds known as acylcarnitines. Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases.
Wf-516
T13339
Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant activit...
Onitisin
TN4713
Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum.
AS19
T10380
AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Ki...
Cyamemazine
T15026
Cyamemazine, contains the phenothiazine chromophore, is a neuroleptic agent used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki: 12 nM), 5-HT2A (Ki: 1.5 nM)...
Sulamserod
T13021
Sulamserod is an antagonist of 5-HT4 receptor, has antiarrhythmic activities.
Pancopride
T16433
Pancopride is a new effective and selective antagonist of the 5-HT3 receptor.
NPS ALX Compound 4a dihydrochloride
T12262L
NPS ALX Compound 4a dihydrochloride is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM)
3-Hydroxy agomelatine
T10114
3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM).
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