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SB 258585

Name: SB 258585
Brand: TargetMol
SKU: T23318L
Price: 121 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T23318LCas号 209480-63-7 一键复制产品信息纯度: 99.77%

很棒

SB 258585 是一种选择性 5-HT6受体拮抗剂。SB 258585 对人重组5-HT6受体的细胞系中的单个受体群体亲和力很高。SB 258585 可用于标记重组和天然5-HT6受体，可用于检测认知增强和抗精神病活性。

SB 258585

一键复制产品信息

很棒

纯度: 99.77%

货号 T23318LCas号 209480-63-7

规格	价格	库存
1 mg	¥ 121	现货
5 mg	¥ 279	现货
10 mg	¥ 475	现货
25 mg	¥ 861	现货
50 mg	¥ 1,500	现货
100 mg	¥ 2,170	现货
200 mg	¥ 3,050	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.77%

颜色: 黄色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

SB 258585 AI Summary

SB 258585 exhibits a high binding affinity and strong selectivity for the human 5-hydroxytryptamine 6 (5-HT6) receptor, with a Ki value of 2.512 nM and a selectivity value greater than 160.0 compared to other serotonin and dopamine receptors. It acts as an antagonist at the human 5-HT6 receptor, inhibiting serotonin-induced cAMP accumulation in human HeLa cells with an IC50 value of 19.0 nM and a significant 97.7% inhibition at 10 μM concentration. Additionally, it demonstrates antagonist activity at mouse 5HT6 receptors, showing the most potent binding to the W6.48A mutant (Ki = 0.32 nM) and varying potency against other mutants. SB 258585 also exhibits bioactivities against various proteins and interactions, including Menin-MLL, JMJD2E, ALDH1A1, 15-human lipoxygenase, and tyrosyl-DNA phosphodiesterase 1, with potency values ranging from 7943.3 nM to 39810.7 nM. Moreover, it displays antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, as well as inhibiting the SARS-CoV-2 3CL-Pro protease. The compound shows a toxicity effect in mouse astrocytes with a CC50 value higher than 1000.0 nM. Lastly, it inhibits Butyrylcholinesterase (BuChE) in human plasma with less than 50.0% inhibition..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

SB 258585 is a selective 5-HT6 receptor antagonist.SB 258585 has a high affinity for individual receptor populations in cell lines with human recombinant 5-HT6 receptors.SB 258585 can be used to label both recombinant and natural 5-HT6 receptors, and can be used to assay cognitive enhancement and antipsychotic activity.

化学信息

分子量	487.36
分子式	C₁₈H₂₂IN₃O₃S
CAS No.	209480-63-7
Smiles	O=S(NC1=CC=C(C(N2CCN(CC2)C)=C1)OC)(C3=CC=C(C=C3)I)=O
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 50 mg/mL (102.59 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0519 mL	10.2594 mL	20.5187 mL	102.5936 mL
5 mM	0.4104 mL	2.0519 mL	4.1037 mL	20.5187 mL
10 mM	0.2052 mL	1.0259 mL	2.0519 mL	10.2594 mL
20 mM	0.1026 mL	0.5130 mL	1.0259 mL	5.1297 mL
50 mM	0.0410 mL	0.2052 mL	0.4104 mL	2.0519 mL
100 mM	0.0205 mL	0.1026 mL	0.2052 mL	1.0259 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。