购物车

您的购物车当前为空

SB 699551 dihydrochloride

Name: SB 699551 dihydrochloride
Brand: TargetMol
SKU: T23325
Price: 286 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.83%

货号 T23325Cas号 864741-95-7

SB 699551 dihydrochloride 是一种5-ht5a 受体拮抗剂。

为众多的药物研发团队赋能，

让新药发现更简单！

SB 699551 dihydrochloride

一键复制产品信息

很棒

纯度: 99.83%

货号 T23325Cas号 864741-95-7

SB 699551 dihydrochloride 是一种5-ht5a 受体拮抗剂。

规格	价格	库存
1 mg	¥ 286	现货
2 mg	¥ 417	现货
5 mg	¥ 696	现货
10 mg	¥ 1,120	现货
25 mg	¥ 2,380	现货
50 mg	¥ 3,400	现货
100 mg	¥ 4,600	现货
500 mg	¥ 9,180	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.83%

联系我们获取更多批次信息

资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

SB 699551 dihydrochloride AI Summary

SB 699551 dihydrochloride exhibits a broad range of bioactivities, including a binding affinity towards the human serotonin transporter (Ki of 25.12 nM) and stimulation of [35S]GTP-gamma-S binding to the 5-Hydroxytryptamine receptor 5A with a pKb of 8.0. In guinea pigs, it shows varying levels of bioavailability, peak blood concentration, half-life, blood clearance, and volume of distribution depending on administration route and dosage. The compound also demonstrates inhibitory effects on cell growth in HEK293T, U2OS, and human fibroblast cell lines, suggesting it can suppress cell proliferation or induce cell death. Additionally, thermal shift assays indicate that SB 699551 dihydrochloride impacts the stability of protein domains, as reflected by changes in melting temperatures. Notably, the compound influences GPCR signaling by inhibiting beta-arrestin recruitment across a range of targets, including FPR2, GLP1R, and CX3CR1, among others, showing strong inhibitory effects on these receptors..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	SB 699551 dihydrochloride is a 5-ht5a receptor antagonist.
靶点活性	5-HT5A receptor:8.3 (pKi)

化学信息

分子量	584.66
分子式	C₃₄H₄₇Cl₂N₃O
CAS No.	864741-95-7
Smiles	Cl.Cl.CN(C)CCN(Cc1ccc(cc1)-c1ccc(CNCCc2ccccc2)cc1)C(=O)CCC1CCCC1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 65 mg/mL (111.18 mM), Sonication is recommended.

Ethanol: < 5.85 mg/mL, Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.42 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7104 mL	8.5520 mL	17.1040 mL	85.5198 mL
5 mM	0.3421 mL	1.7104 mL	3.4208 mL	17.1040 mL
10 mM	0.1710 mL	0.8552 mL	1.7104 mL	8.5520 mL
20 mM	0.0855 mL	0.4276 mL	0.8552 mL	4.2760 mL
50 mM	0.0342 mL	0.1710 mL	0.3421 mL	1.7104 mL
100 mM	0.0171 mL	0.0855 mL	0.1710 mL	0.8552 mL