Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cericlamine 是一种选择性5-羟色胺(5-HT)再摄取阻滞剂 具有抗抑郁活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 910 | 现货 | ||
5 mg | ¥ 2,230 | 现货 | ||
10 mg | ¥ 3,350 | 现货 | ||
25 mg | ¥ 5,460 | 现货 | ||
50 mg | ¥ 7,670 | 现货 | ||
100 mg | ¥ 9,870 | 现货 | ||
500 mg | ¥ 19,800 | 现货 |
产品描述 | Cericlamine is a selective 5-hydroxytryptamine (5-HT) reuptake blocker with antidepressant activity. |
体内活性 | Cericlamine was injected for 2 weeks at a dose (16 mg/kg i.p., twice daily) that ensured complete prevention of 4-methyl-alpha-ethyl-meta-tyramine-induced depletion of brain serotonin. In vitro binding and quantitative autoradiographic studies showed that neither 5-HT1A, 5-HT2A, 5-HT2C nor 5-HT3 receptor binding sites in various brain areas were affected by the 14-day treatment with cericlamine. Although forskolin-stimulated adenylate cyclase activity was significantly increased in hippocampal homogenates from cericlamine-treated rats, the reduction in this enzymatic activity due to 5-HT1A receptor stimulation by 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) was unchanged in these animals as compared with controls. Thus the potency of 8-OH-DPAT and ipsapirone to depress the firing rate of these neurons in brain stem slices was significantly reduced after the 2-week treatment with cericlamine. In vivo, the potency of an injection of cericlamine to inhibit the discharge of serotoninergic neurons was also markedly less in rats that had been pretreated for 2 weeks with this drug as compared with controls.[1] |
分子量 | 262.18 |
分子式 | C12H17Cl2NO |
CAS No. | 112922-55-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (171.64 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.8142 mL | 19.0709 mL | 38.1417 mL | 95.3543 mL |
5 mM | 0.7628 mL | 3.8142 mL | 7.6283 mL | 19.0709 mL | |
10 mM | 0.3814 mL | 1.9071 mL | 3.8142 mL | 9.5354 mL | |
20 mM | 0.1907 mL | 0.9535 mL | 1.9071 mL | 4.7677 mL | |
50 mM | 0.0763 mL | 0.3814 mL | 0.7628 mL | 1.9071 mL | |
100 mM | 0.0381 mL | 0.1907 mL | 0.3814 mL | 0.9535 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cericlamine 112922-55-1 GPCR/G Protein Neuroscience 5-HT Receptor Inhibitor inhibitor inhibit