Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 10-14周 | ||
50 mg | ¥ 13,800 | 10-14周 | ||
100 mg | ¥ 17,500 | 10-14周 |
产品描述 | SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1]. |
体外活性 | SB-258741 behaves as a partial inverse agonist, the antagonist potency (apparent pK B ) is 8.47 [2]. |
体内活性 | SB 258741 (0-9.1 mg/kg; s.c.; once or daily for 3 days) shows antipsychotic effects in rats [1]. Animal Model: Male Wistar rats, 250 –300 g in the phencyclidine (PCP)-disrupted prepulse inhibition (PPI) and PCP-disrupted social interaction (SIT) paradigm, 200 – 250 g in the catalepsy, motility, and D-amphetamine hyperactivity paradigms [1] Dosage: 0.56, 2.3, 4.6 and 9.1 mg/kg Administration: Subcutaneous injection, once or daily for 3 days (social interaction test) Result: Reversed hyperactivity induced by D-amphet-amine over 0.56 mg/kg, and reduced motility at 4.6 and 9.1 mg/kg. Did not reverse D-Amphetamine-disrupted PPI, but enhanced PCP-disrupted PPI. Reduced PCP (2 mg/kg)-induced hyperactivity. |
分子量 | 386.98 |
分子式 | C19H31ClN2O2S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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