Ramosetron

Name: Ramosetron
Brand: TargetMol
SKU: T4562
Price: 133 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 98.84%

货号 T4562Cas号 132036-88-5

别名 雷莫司琼碱基

Ramosetron 是一种血清素 5-HT3 受体拮抗剂，用于治疗恶心和呕吐。它被认为比其他一代 5-HT3 拮抗剂如昂丹司琼具有更高的效力和更长的止吐作用。它还适用于治疗“男性以腹泻为主的肠易激综合征”。它仅获准在日本和选定的东南亚国家使用。

Ramosetron

一键复制产品信息

很棒

纯度: 98.84%

货号 T4562 别名 雷莫司琼碱基Cas号 132036-88-5

规格	价格	库存
5 mg	¥ 153	现货
10 mg	¥ 215	现货
25 mg	¥ 389	现货
50 mg	¥ 568	现货
100 mg	¥ 853	现货
200 mg	¥ 1,270	现货
1 mL x 10 mM (in DMSO)	¥ 133	现货

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产品介绍

Ramosetron AI Summary

Ramosetron is a multifunctional molecule displaying a variety of bioactivities. It shows strong binding affinity to the human 5HT3A receptor with a Ki of 0.06 nM and demonstrates partial agonist activity at this receptor by reducing intracellular calcium release at 3 µM in HEK293 cells. In the PUBCHEM_BIOASSAY S16 Schwann cell viability assay, it has a potency of 3.2 nM. Additionally, it exhibits antiviral activity against the SARS-CoV-2 virus in several assays; it showed moderate antiviral activity in HRCE cells against the USA-WA1/2020 strain at MOI 0.4 for 96 hrs, inhibited SARS-CoV-2 3CL-Pro protease activity by 14.21% at 20 µM, and showed inhibition of SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM. However, the potency in inhibiting the virus indicated by IC50 values (>20000.0 nM and >19952.62 nM) suggests limited efficacy at tested concentrations. Furthermore, Ramosetron exhibits inhibitory activity on the human HDAC6 enzyme with -23.53% inhibition using a commercial peptide substrate and 3.12% inhibition with a custom peptide substrate. It also shows binding affinity to several other receptors, including ADRA2B, OPRK1, and ADRA2A, with various AC50 values, and functions as an antagonist at ADRA2A and an agonist at HRH2, ADRA2A, and PGR with relatively low efficacy at specified concentrations..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

Ramosetron is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting. It is believed to have higher potency and longer antiemetic action than other 1st generation 5-HT3 antagonists such as ondansetron. Ramosetron is also indicated for a treatment of "diarrhea-predominant irritable bowel syndrome in males". It is only licensed for use in Japan and selected Southeast Asian countries.

别名

雷莫司琼碱基

化学信息

分子量	279.34
分子式	C₁₇H₁₇N₃O
CAS No.	132036-88-5
Smiles	C(=O)(C=1C=2C(N(C)C1)=CC=CC2)[C@H]3CC4=C(CC3)N=CN4
密度	1.33g/cm3
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (161.09 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5799 mL	17.8993 mL	35.7987 mL	178.9933 mL
5 mM	0.7160 mL	3.5799 mL	7.1597 mL	35.7987 mL
10 mM	0.3580 mL	1.7899 mL	3.5799 mL	17.8993 mL
20 mM	0.1790 mL	0.8950 mL	1.7899 mL	8.9497 mL
50 mM	0.0716 mL	0.3580 mL	0.7160 mL	3.5799 mL
100 mM	0.0358 mL	0.1790 mL	0.3580 mL	1.7899 mL