Natriuretic peptide

Imelciment(REGN-9035)是一种靶向NPR1的人源化单克隆抗体，可用于研究心力衰竭。

dCNP 结合 NPR-B/C 受体 (NPR-B/C receptor)，激活 cGMP 信号通路以调节血管功能。通过下调 HIF1α、HIF2α 等基因，dCNP 发挥抗缺氧作用，并抑制肿瘤基质诱导，体现其抗纤维化效能。同时，dCNP 上调肿瘤中的 CTL、NK 细胞和常规 1 型树突状细胞，增强免疫反应。

A 71915, an atrial natricuretic factor receptor antagonist, blocks physiological effects of angiotensin.

NPRA agonist-11 (Example 161) 是一种NPRA (NPR1)激动剂，对人类和猴子的AC50值分别为1.681 μM和0.989 μM。NPRA agonist-11 可用于研究心血管相关疾病。

ANP [Des18-22] 4-23 amide rat 是大鼠的心房利钠肽（ANP）多肽片段，能够特异性结合NPR-C。

Ethiazide is a benzothiadiazine sulfonamide derivative belonging to the class of the thiazide diuretics.

BNP (1-21), Pro (Human) 是一种由21个氨基酸组成的心脏激素多肽。作为B型利钠肽(BNP)的一部分，与心房利钠肽高度同源，共同构成了心脏的双利钠肽系统。BNP 主要参与心脏发生的调节，并涉及向子宫外环境过渡的生理进程。

Urodilatin为ANF-(99-126)的同类物，属于利尿钠调节肽。该化合物主要应用于急性肾功能衰竭、充血性心力衰竭、支气管哮喘等疾病的研究领域。

Anaritide是一种由25个氨基酸组成的合成心脏利钠肽（ANP）。它通过扩张入球小动脉和收缩出球小动脉来提升肾小球滤过率。Anaritide用于研究其对急性肾小管坏死患者的影响，尤其是在提高透析自由生存率方面。

Baloncibart 是一种针对 NPR1 的 IgG4K 型人源抗体。

Mouse Brain Natriuretic Peptide-45 (BNP-45, mouse) is a circulating variant of the mouse brain natriuretic peptide derived from the mouse heart. It exhibits powerful hypotensive and natriuretic properties.

Brain Natriuretic Peptide-45, rat TFA (BNP-45, rat TFA) 为来源于大鼠心脏的脑利钠肽循环同源物，具有显著的降压和利尿效果。

Ularitide is a 32-amino acid peptide derived from (95-126 residues) of ANP PROHORMONE (1-126 residues). It isn't biologically inactivated by a peptidase from dog kidney cortex membranes.

BNP-45 (rat) is a circulating form of rat brain natriuretic peptide isolated from rat heart with potent hypotensive and natriuretic potency.

Vixticibart，一种IgG4κ型人源抗体，靶向NPR1。其同型对照为HumanIgG4(S228P) kappa, Isotype Control。

REGN-7544是一种靶向NPR1的人源化单克隆抗体，能够阻断和抑制NPR1从而升高血压，可用于研究低血压，脓毒性休克和体位性心动过速综合征。

AP 811, a selective antagonist of the atrial natriuretic peptide clearance receptor (APN-CR, NPR3) with a K i value of 0.48 nM, exhibits remarkable selectivity for NPR3 over NPR1 by more than 20,000-fold. Moreover, AP 811 effectively eliminates ANP-induced pump stimulation.

Atriopeptin III (ANP 127-150) (rat)是包含24个氨基酸的心房肽，作用为有效的血管舒张剂及利尿剂。在输尿管梗阻大鼠模型中，Atriopeptin III (rat)能够改善肾功能并降低血压，同时适用于慢性肾功能衰竭研究。

Nesiritide is the recombinant form of the 32 amino acid human B-type natriuretic peptide, which is normally produced by the ventricular myocardium. It is an agonist of natriuretic peptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR

Nesiritide, a 32-amino acid natriuretic peptide and recombinant form of human brain natriuretic peptide, enhances vasorelaxation ex vivo in porcine hearts from an acute coronary occlusion model when given as a 2 µg/kg bolus dose followed by a 0.01 µg/kg per minute infusion, facilitated by the calcium ionophore A23187. Formulations containing nesiritide have been utilized in managing congestive heart failure.