Clomipramine

Name: Clomipramine
Brand: TargetMol
SKU: T21013
Price: 109 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.71%

货号 T21013Cas号 303-49-1

别名 氯米帕明, Clomipramina, Clomicalm, Chlorimipramine, Anafranil (free base), Anafranil

Clomipramine (Clomicalm) 是一种三环类抗抑郁药，能够有效阻断 5-HT 再摄取 (IC50:1.5 nM) ，可用于研究强迫症 (OCD) 及抑郁症。

Clomipramine

一键复制产品信息

很棒

纯度: 99.71%

货号 T21013 别名 氯米帕明, Clomipramina, Clomicalm, Chlorimipramine, Anafranil (free base), AnafranilCas号 303-49-1

Clomipramine (Clomicalm) 是一种三环类抗抑郁药，能够有效阻断 5-HT 再摄取 (IC50:1.5 nM) ，可用于研究强迫症 (OCD) 及抑郁症。

规格	价格	库存
2 mg	¥ 109	现货
5 mg	¥ 159	现货
10 mg	¥ 218	现货
25 mg	¥ 345	现货
50 mg	¥ 533	现货
100 mg	¥ 792	现货
200 mg	¥ 1,170	现货
1 mL x 10 mM (in DMSO)	¥ 206	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.71%

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Clomipramine AI Summary

Clomipramine exhibits a range of bioactivities, primarily involving the inhibition of neurotransmitter reuptake and various receptor bindings. It is notably potent in inhibiting norepinephrine (IC50 = 900 nM) and serotonin (IC50 = 90 nM) accumulation in mouse brain slices and exhibits antidepressant activity by inhibiting tetrabenazine (TBZ) ptosis and potentiating 5-hydroxytryptophan-induced head twitches in rats. Additionally, it demonstrates high affinity interactions with the dopamine D2, alpha-1 adrenergic, and serotonin receptors, with Ki values indicating significant binding strength, and shows inhibitory effects on multiple neurotransmitter transporters and voltage-dependent sodium channels. The compound also presents cytotoxicity and antitrypanosomal actions against Trypanosoma cruzi amastigotes, suggesting potential anti-parasitic applications. Long-term biological effects include a high volume of distribution, indicating extensive tissue penetration, and significant metabolic interactions with liver enzymes. Despite exhibiting some beneficial therapeutic activities, Clomipramine also has potential for neurotoxicity and hepatotoxicity, which necessitates careful consideration in therapeutic contexts..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Clomipramine (Clomicalm) is a tricyclic antidepressant (TCA). It is used for the treatment of the panic disorder, obsessive-compulsive disorder, major depressive disorder, and chronic pain. It may decrease the risk of suicide in those over the age of 65. It is similar to Imipramine in that selective inhibition of the serotonin uptake in the brain.
别名	氯米帕明, Clomipramina, Clomicalm, Chlorimipramine, Anafranil (free base), Anafranil

化学信息

分子量	314.85
分子式	C₁₉H₂₃ClN₂
CAS No.	303-49-1
Smiles	CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc12
密度	1.119 g/cm3

储存&溶解度

存储

keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 120 mg/mL (381.13 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.35 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1761 mL	15.8806 mL	31.7612 mL	158.8058 mL
5 mM	0.6352 mL	3.1761 mL	6.3522 mL	31.7612 mL
10 mM	0.3176 mL	1.5881 mL	3.1761 mL	15.8806 mL
20 mM	0.1588 mL	0.7940 mL	1.5881 mL	7.9403 mL
50 mM	0.0635 mL	0.3176 mL	0.6352 mL	3.1761 mL
100 mM	0.0318 mL	0.1588 mL	0.3176 mL	1.5881 mL