规格

价格

库存

数量

25 mg

¥ 10,600

6-8周

50 mg

¥ 13,800

6-8周

100 mg

¥ 17,500

6-8周

生物活性

产品描述

Bopindolol is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol is a prodrug of pindolol and can be rapidly metabolized to an active hydrolyzed form. Bopindolol can be used for essential and renovascular hypertension research [1] [2].

体内活性

Bopindolol (intravenous injection; l8, 16 and 32 μg/kg) dose-dependently inhibits isoprenaline-induced tachycardia, and this agent is 4 times more potent than propranolol in anaesthetised dogs [1]. Bopindolol (intraperitoneal injection; 3.0 mg/kg) reduces the diastolic blood pressure (DBP) in pithed rats. And pindolol (1.0 mg/kg) produces similar decreases in DBP of about 8 mmHg. it also produces a dose-dependent decrease in heart rate [2].

化学信息

分子量	380.48
分子式	C₂₃H₂₈N₂O₃
CAS No.	62658-63-3
Smiles	O(CC(OC(=O)C1=CC=CC=C1)CNC(C)(C)C)C2=C3C(NC(C)=C3)=CC=C2
密度	1.143 g/cm3 (Predicted)