PNU 22394 hydrochloride

Name: PNU 22394 hydrochloride
Brand: TargetMol
SKU: T23168
Price: 428 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T23168Cas号 15923-42-9 一键复制产品信息纯度: 97.83%

很棒

PNU 22394 hydrochloride 是一种 5-HT2C 激动剂和部分 5-HT2A/5-HT2B 激动剂。

PNU 22394 hydrochloride

一键复制产品信息

很棒

纯度: 97.83%

货号 T23168Cas号 15923-42-9

PNU 22394 hydrochloride 是一种 5-HT2C 激动剂和部分 5-HT2A/5-HT2B 激动剂。

规格	价格	库存
1 mg	¥ 428	现货
5 mg	¥ 987	现货
10 mg	¥ 1,450	现货
25 mg	¥ 2,380	现货
50 mg	¥ 3,510	现货
100 mg	¥ 4,870	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 97.83%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

PNU 22394 hydrochloride AI Summary

PNU 22394 hydrochloride demonstrates a diverse range of bioactivities. It acts as an inhibitor of HSD17B4 (hydroxysteroid dehydrogenase 4) with a potency of 25118.9 nM, JMJD2E (Jumonji Domain Containing 2E) with a potency of 35481.3 nM, and 15-hLO (15-human lipoxygenase) with a potency of 39810.7 nM. Additionally, it inhibits 15-hLO-2 (15-human lipoxygenase 2) at a potency of 19952.6 nM and the ERK signaling pathway when stimulated with EGF, also at 35481.3 nM. Furthermore, it demonstrates the capacity to erase genomic imprints at a potency of 10000.0 nM, and it inhibits anthrax lethal toxin internalization at a potency of 5011.9 nM. In antiviral research, PNU 22394 hydrochloride inhibits SARS-CoV-2 induced cytotoxicity of Caco-2 cells at a 10 uM concentration after 48 hours, showing an inhibition rate of 0.61%. It also inhibits SARS-CoV-2 induced cytotoxicity of VERO-6 cells at the same concentration, with an inhibition rate of -0.08% after 48 hours exposure to 0.01 MOI SARS-CoV-2 virus. In enzymatic assays, it shows inhibitory activity against SARS-CoV-2 3CL-Pro protease at a concentration of 20 µM, though with a recorded inhibition of -3.642% as measured via a FRET assay..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	PNU 22394 hydrochloride is a 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist

化学信息

分子量	236.74
分子式	C₁₃H₁₇ClN₂
CAS No.	15923-42-9
Smiles	CN1C(CCNCC2)=C2C3=C1C=CC=C3.[H]Cl
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

H2O: 23 mg/mL (97.15 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	4.2240 mL	21.1202 mL	42.2404 mL	211.2022 mL
5 mM	0.8448 mL	4.2240 mL	8.4481 mL	42.2404 mL
10 mM	0.4224 mL	2.1120 mL	4.2240 mL	21.1202 mL
20 mM	0.2112 mL	1.0560 mL	2.1120 mL	10.5601 mL
50 mM	0.0845 mL	0.4224 mL	0.8448 mL	4.2240 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。