MDL 100009

Name: MDL 100009
Brand: TargetMol
SKU: T22359
Price: 1010 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 98.96%

货号 T22359Cas号 175673-57-1

MDL 100009 是 MDL 100151 的 S-对映体和 MDL 100907 的相反对映体，是 5-HT2A 的选择性拮抗剂。

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MDL 100009

一键复制产品信息

很棒

纯度: 98.96%

货号 T22359Cas号 175673-57-1

MDL 100009 是 MDL 100151 的 S-对映体和 MDL 100907 的相反对映体，是 5-HT2A 的选择性拮抗剂。

规格	价格	库存
1 mg	¥ 1,010	现货
5 mg	¥ 2,070	现货
10 mg	¥ 3,110	现货
25 mg	¥ 4,530	现货
50 mg	¥ 6,210	现货
100 mg	¥ 8,190	现货
200 mg	¥ 11,000	现货
1 mL x 10 mM (in DMSO)	¥ 2,310	现货

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COA LCMS HNMR 产品操作手册

产品介绍

MDL 100009 AI Summary

MDL 100009 exhibits high affinity for human 5-hydroxytryptamine 2A receptors (Ki between 0.1 and 0.57 nM), indicating potent antagonist activity which may affect serotonergic pathways involved in mood, cognition, and perception. It also shows moderate affinity for human 5-hydroxytryptamine 2C receptors (Ki around 13 nM) and low affinity for dopamine D2 receptors (Ki between 1300 nM and 2250 nM). MDL 100009 inhibits the human hERG channel with a Ki of 1100 nM and demonstrates antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in VERO-6 cells, although with moderate potency (IC50 >20000 nM). Pharmacokinetic properties include a maximum blood concentration of 5.355 nM after an oral dose of 1.2 mg/kg, an area under the concentration-time curve of 8.0 ng.hr.mL-1, a bioavailability of 3.0%, plasma clearance of 77.0 ml min-1 kg-1, and a volume of distribution of 4.6 L.kg-1. MDL 100009 also shows a range of effects on cell viability and protein stability in various assays, suggesting complex bioactivity which may vary depending on the biological context..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	MDL 100009, the S-enantiomer of MDL 100151 and the opposite enantiomer of MDL 100907, is a selective antagonist of 5-HT2A.

化学信息

分子量	373.46
分子式	C₂₂H₂₈FNO₃
CAS No.	175673-57-1
Smiles	[C@@H](O)(C1=C(OC)C(OC)=CC=C1)C2CCN(CCC3=CC=C(F)C=C3)CC2
密度	1.150 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 10 mg/mL (26.78 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6777 mL	13.3883 mL	26.7766 mL	133.8831 mL
5 mM	0.5355 mL	2.6777 mL	5.3553 mL	26.7766 mL
10 mM	0.2678 mL	1.3388 mL	2.6777 mL	13.3883 mL
20 mM	0.1339 mL	0.6694 mL	1.3388 mL	6.6942 mL