PNU-96391

Name: PNU-96391
Brand: TargetMol
SKU: T28435
Price: 468 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.53%

货号 T28435Cas号 146798-66-5

别名 PNU96391, PNU 96391, OSU-6162, OSU6162, OSU 6162

PNU-96391 (OSU-6162) 是多巴胺 D2 的拮抗剂和 5-HT2A 的部分激动剂。 PNU-96391可用于治疗慢性病的研究。

PNU-96391

一键复制产品信息

很棒

纯度: 99.53%

货号 T28435 别名 PNU96391, PNU 96391, OSU-6162, OSU6162, OSU 6162Cas号 146798-66-5

PNU-96391 (OSU-6162) 是多巴胺 D2 的拮抗剂和 5-HT2A 的部分激动剂。 PNU-96391可用于治疗慢性病的研究。

规格	价格	库存
1 mg	¥ 468	现货
5 mg	¥ 1,050	现货
10 mg	¥ 1,550	现货
25 mg	¥ 2,470	现货
50 mg	¥ 3,350	现货
100 mg	¥ 4,500	现货
200 mg	¥ 5,920	现货
1 mL x 10 mM (in DMSO)	¥ 942	现货

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COA HNMR LCMS 产品操作手册

产品介绍

PNU-96391 AI Summary

PNU-96391 demonstrates bioactivity across multiple neurotransmitter systems and behaviors in rat models. It has affinity for dopamine D2 receptors (with Ki values of 3884.0 nM at low affinity and 755.0 nM at high affinity) and dopamine D3 receptors, while showing no activity at dopamine D2L receptors. It affects both limbic and striatal regions, influencing DOPA and DOPAC levels and reducing 5-HIAA levels. This compound alters extracellular dopamine levels and 5-hydroxytryptamine 1A receptor activity, impacting dopamine release and locomotor behavior. Subcutaneously administered at a dose of 100 umol/kg, it reduces spontaneous locomotor activity by 215%, decreases 5-HIAA levels, and increases DOPAC levels in the striatum. Additionally, it attenuates amphetamine-induced locomotor activity by 37%. Pharmacokinetic data indicate moderate to high clearance in rat, monkey, and dog models, suggesting efficient elimination and varying tissue distribution. PNU-96391 also exhibits antiviral activity against SARS-CoV-2, with an IC50 greater than 20000.0 nM in VERO-6 cell assays. These bioactivity profiles suggest potential for further exploration as a drug candidate..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	PNU-96391 (OSU-6162) is an antagonist of dopamine D2 and a partial agonist of 5-HT2A. PNU-96391 can be used in research on the treatment of chronic diseases.
别名	PNU96391, PNU 96391, OSU-6162, OSU6162, OSU 6162

化学信息

分子量	281.41
分子式	C₁₅H₂₃NO₂S
CAS No.	146798-66-5
Smiles	S(C)(=O)(=O)C=1C=C(C=CC1)[C@H]2CN(CCC)CCC2
密度	1.093g/cm3

储存&溶解度

存储

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (195.44 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5535 mL	17.7677 mL	35.5353 mL	177.6767 mL
5 mM	0.7107 mL	3.5535 mL	7.1071 mL	35.5353 mL
10 mM	0.3554 mL	1.7768 mL	3.5535 mL	17.7677 mL
20 mM	0.1777 mL	0.8884 mL	1.7768 mL	8.8838 mL
50 mM	0.0711 mL	0.3554 mL	0.7107 mL	3.5535 mL
100 mM	0.0355 mL	0.1777 mL	0.3554 mL	1.7768 mL