Promethazine

Name: Promethazine
Brand: TargetMol
SKU: T0445
Price: 108 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.76%

货号 T0445Cas号 60-87-7

别名 异丙嗪, Proazamine, Diphergan

Promethazine (Proazamine) 是抗青光眼前列腺素（PG）的类似物。

Promethazine

一键复制产品信息

很棒

纯度: 99.76%

货号 T0445 别名 异丙嗪, Proazamine, DipherganCas号 60-87-7

Promethazine (Proazamine) 是抗青光眼前列腺素（PG）的类似物。

规格	价格	库存
5 mg	¥ 108	现货
10 mg	¥ 142	现货
25 mg	¥ 215	现货
50 mg	¥ 295	现货
100 mg	¥ 433	现货
500 mg	¥ 987	现货
1 mL x 10 mM (in DMSO)	¥ 197	现货

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产品介绍

Promethazine AI Summary

Promethazine is a multi-faceted compound exhibiting a diverse range of biological activities. It inhibits the binding of Batrachotoxinin [3H]BTX-B to voltage-dependent sodium channels in guinea pig cerebral cortex with an IC50 of 6900.0 nM, achieving 61% inhibition at a concentration of 10 µM. It also demonstrates antimicrobial activity against Plasmodium falciparum with an IC50 of 20000.0 nM and against Trypanosoma cruzi Trypanothione reductase with an IC50 of 271000.0 nM and a Ki of 216000.0 nM. Additionally, it inhibits half-maximal Prion protein PrPsc formation in ScN2a cells with an EC50 of 8000.0 nM. Physicochemically, Promethazine has a pKa ranging around 8.9 to 9.1, a logP of 4.81, and a logD7.4 of 2.67, indicating high plasma protein binding (92.95%). The compound shows a volume of distribution (Vdss) of 14.0 L.kg-1, total body clearance of 14.0 mL.min-1.kg-1, and renal clearance of 0.14 mL.min-1.kg-1. It has significant protein binding characteristics with a low fraction unbound (Fu) of 0.07. In cellular assays, Promethazine shows various inhibitory activities including Na+/K+ ATPase in rat brain and histamine release from rat mast cells. It inhibits acid sphingomyelinase (ASM) in rat PC12 cells, demonstrating residual activity of 32.2% at 10 µM. It also shows higher LDH enzyme levels impacting liver and muscle health markers. Its histone lysine methyltransferase inhibition indicates potential epigenetic modulation. Also, Promethazine has shown consistency in antiviral assays by inhibiting SARS-CoV-2 in VERO-6 cells with varying IC50 values and inducing limited liver toxicity. It demonstrates inhibitory activities on human CaV2.2 and quorum sensing systems in various bacteria strains. Its impact on clathrin-mediated endocytosis is notable with an IC50 of 7480.0 nM. Overall, Promethazine's extensive bioactivity profile, including receptor binding, enzyme inhibition, antimicrobial actions, and physicochemical properties, suggests potential therapeutic applications across multiple disease models, necessitating further investigation into its biological interactions and therapeutic efficacy..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Promethazine (Proazamine) is an analogue of anti-glaucoma prostaglandin (PG) .
别名	异丙嗪, Proazamine, Diphergan

化学信息

分子量	284.42
分子式	C₁₇H₂₀N₂S
CAS No.	60-87-7
Smiles	CC(CN1C2=C(SC3=C1C=CC=C3)C=CC=C2)N(C)C
密度	1.131

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 11.01 mg/mL (38.71 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.03 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5159 mL	17.5796 mL	35.1593 mL	175.7964 mL
5 mM	0.7032 mL	3.5159 mL	7.0319 mL	35.1593 mL
10 mM	0.3516 mL	1.7580 mL	3.5159 mL	17.5796 mL
20 mM	0.1758 mL	0.8790 mL	1.7580 mL	8.7898 mL