517
113
3
310
Cat. No. | Product Name | ||
---|---|---|---|
L7200 | 钙通道分子库 | 140 compounds | |
140 种钙通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L5400 | 抗心血管疾病化合物库 | 1408 compounds | |
1408 种心血管疾病相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L9830 | 抗帕金森病化合物库 | 857 compounds | |
857 种帕金森病相关的化合物集合,可用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1889 |
CP-640186
CP 640186 |
Acetyl-CoA Carboxylase | Metabolism |
CP-640186 是一种有效的乙酰辅酶 A 羧化酶 (ACC)抑制剂,抑制大鼠肝脏 ACC1 和大鼠骨骼肌 ACC2 的 IC50分别为 53 nM 和 61 nM。 | |||
T3622 |
CP-640186 hydrochloride
CP 640186 HCl,盐酸CP-640186 |
Acetyl-CoA Carboxylase | Metabolism |
CP-640186 hydrochloride (CP 640186 HCl) 是膜渗透性的乙酰辅酶A 羧化酶(ACC)抑制剂,抑制大鼠肝脏ACC1和大鼠骨骼肌ACC2的IC50为53 nM 和61 nM。 | |||
T3563 |
Lvguidingan
|
Others | Others |
Lvguidingan 是一种抗惊厥药。 | |||
T11831 |
LDN-27219
|
Others | Others |
LDN-27219 是一种人组织型转谷氨酰胺酶抑制剂(IC50:600 nM)。 | |||
T6792 |
BQ-123
BQ123 |
Endothelin Receptor | GPCR/G Protein |
BQ-123 是高效的内皮素 A(ETA)受体选择性拮抗剂,其IC50=7.3 nM,Ki=25 nM。它能够降低高血压大鼠血压,抑制内皮素-1 介导的人肺动脉平滑肌细胞增殖。 | |||
T8760 |
NNMTi
5-Amino-1-methylquinolinium |
Others | Others |
NNMTi (5-Amino-1-methylquinolinium) 是烟酰胺 N -甲基转移酶的抑制剂 (IC50=1.2 μM),可选择性地结合 NNMT 底物结合位点残基。它能诱导体外成肌细胞分化,提高老年小鼠肌肉干细胞融合和再生能力。 | |||
T8452 |
Dantrolene
|
Others | Others |
Dantrolene 是一种肌肉松弛剂,是人红细胞谷胱甘肽还原酶的非竞争性抑制剂,其Ki 和IC50值分别为 111.6 μM 和 52.3 μM。它是兰尼碱受体拮抗剂及Ca2+信号稳定剂。它可用于研究恶性高热、亨廷顿病、肌肉痉挛和其他神经阻滞剂恶性综合征。 | |||
T1409 |
Methocarbamol
Lumirelax,美索巴莫,Metocarbamol,AHR 85,Robaxin |
Sodium Channel; Carbonic Anhydrase | Membrane transporter/Ion channel; Metabolism |
Methocarbamol (AHR 85) 是口服有效的中枢肌肉松弛剂,可阻断肌肉Nav1.4通道,阻断作用具有可逆性。Methocarbamol 具有用于肌肉痉挛和疼痛综合症研究的潜力。 | |||
T5458 |
Darusentan
Lu-135252,达卢生坦 |
Endothelin Receptor | GPCR/G Protein |
Darusentan (Lu-135252) 是内皮素受体 A (ET-A) 受体选择性拮抗剂,能够作用于 ET-A 受体(Ki:1.4 nM)及ET-B 受体(Ki:184 nM),对 ETA 受体的选择性大于 ETB 受体的100以上。它在大鼠主动脉血管平滑肌细胞膜中竞争结合放射性标记的内皮素(Ki:13 nM)。 | |||
T22967 |
MEDICA16
MEDICA 16 |
GPR; Others; ATP Citrate Lyase | Endocrinology/Hormones; GPCR/G Protein; Metabolism; Others |
MEDICA16 是 GPR40 的特异性激动剂以及 GPR120 的部分激动剂。 MEDICA16 是一种 ATP-柠檬酸裂解酶抑制剂,可显着降低腓肠肌中的细胞内 TG 含量,同时增加胰岛素敏感性。 | |||
T23322 |
SB 452533
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
SB 452533 是TRPV1的选择性拮抗剂,pKb 为 7.8。 | |||
T22459 |
Xanthinol Nicotinate
Angioamin,烟酸占替诺,Complamin |
Others | Others |
Xanthinol Nicotinate (Complamin) 是血管扩张剂,可直接作用于小动脉和毛细血管的平滑肌,能够扩大血管,改善血液流变学并降低外周血管阻力。 | |||
T0145 |
Felodipine
非洛地平,CGH-869 |
Calcium Channel; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Felodipine (CGH-869) 是一种长效的 1, 4-二氢吡啶钙通道抑制剂,可跨越血脑屏障,可诱导自噬,具有抗高血压活性。它通过选择性作用于血管平滑肌,尤其是阻力血管来降低血压。 | |||
T8405 |
Vardenafil hydrochloride
伐地那非,盐酸伐地那非 |
PDE | Metabolism |
Vardenafil hydrochloride 是口服具有活性的、高效的、选择性的磷酸二酯酶 5抑制剂。它对 PDE1 (180 nM),PDE6 (11 nM),PDE2,PDE3,PDE4 (>1000 nM) 具有选择性。它能够非竞争性地抑制环磷酸鸟苷水解,提高 cGMP 水平。它可用于勃起功能障碍的研究。 | |||
T10492 |
BD-AcAc 2
Ketone Ester |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
BD-AcAc 2 (Ketone Ester) 是一种酮单酯,是口服营养酮的来源。小鼠口服 BD-AcAc 2 后可提高血浆 乙酰乙酸和β-羟基丁酸水平、血液钠离子、血糖水平和血肌酐水平。BD-AcAc 2 可以一定程度预防脓毒症小鼠的肌无力。BD-AcAc 2 显示出提高动物机体耐力和运动能力的潜力。BD-AcAc 2 还可用于研究糖尿病或帕金森病。 | |||
T7133 |
Anagliptin
SK-0403,阿拉格列汀 |
Proteasome; DPP-4 | Proteases/Proteasome; Ubiquitination |
Anagliptin (SK-0403) 是一种选择性的二肽酰肽酶 4 抑制剂,IC50=3.8 nM,对 DPP-8/9 的选择性相对较弱,IC50分别为 68 和 60 nM。 | |||
T6579 |
Medetomidine hydrochloride
MPV785,Medetomidine HCl,Domitor |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Medetomidine hydrochloride (MPV785) 是一种 α2 肾上腺素受体激动剂,能够作用于α2和α1肾上腺素受体,其Ki 分别为1.08 nM 和1750 nM。 | |||
T1594 |
Vecuronium bromide
ORG NC 45,维库溴铵 |
AChR | Neuroscience |
Vecuronium bromide (ORG NC 45) 是一种合成的中效单季铵盐类固醇和非去极化神经肌肉阻滞剂,具有肌肉松弛活性。 | |||
T1072 |
Loxeen
Pridinol methanesulfonate,Α,Α-二苯基-1-哌啶丙醇(普立地诺 甲磺酸盐 ) |
AChR | Neuroscience |
Loxeen (Pridinol methanesulfonate) 用作抗胆碱能药物和抗帕金森病药物。 | |||
T22371 |
Mivacurium dichloride
米库氯铵,Mivacurium chloride,二氯美维库铵 |
AChR | Neuroscience |
Mivacurium dichloride (Mivacurium chloride) 是苄基异喹啉衍生物,可与 nAChR 偶联,以减少或抑制乙酰胆碱对肌肉细胞末端盘的去极化作用。它也是非去极化短效的神经肌肉阻滞剂和骨骼肌松弛剂。 | |||
T1092 |
Zolmitriptan
佐米曲普坦,311C90,BW-311C90 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Zolmitriptan (311C90) 是一种5-HT1B/1D 受体部分激动剂,可用于偏头痛的研究,对 5-HT1B、5-HT1D、5-HT1F 受体的Ki 分别为 5.01、0.63 和 63.09 nM。 | |||
T7144 |
BTS
N-Tosylbenzylamine,N-苄基-对甲苯磺酸胺,N-Benzyl-p-toluenesulfonamide |
ATPase; Myosin | Cytoskeletal Signaling; Membrane transporter/Ion channel |
BTS (N-Tosylbenzylamine) 是一种选择性骨骼肌肌球蛋白 II 亚片段 1 (S1) ATPase 活性抑制剂,可特异性抑制骨骼肌快速纤维的收缩。它对肌动蛋白和 Ca2+刺激的肌球蛋白 S1 ATPase 的 IC50值约为 5 µM。 | |||
T0992 |
Carbenoxolone disodium
Biogastrone,Duogastrone,甘珀酸钠,Bioral |
Gap Junction Protein | Cytoskeletal Signaling |
Carbenoxolone disodium (Duogastrone) 是甘草酸的活性代谢物和人11β-HSD 和细菌3α, 20β-HSD 的抑制剂。它是一种缝隙连接的解耦剂,可抑制牛痘病毒生长,用于消化性、食道和口腔溃疡和炎症的相关研究。 | |||
T8815 |
Azumolene
阿珠莫林,EU4093 free base |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Azumolene (EU4093 free base) 是一种 Dantrolene 的类似物,是一种肌肉松弛剂,可用于恶性高热研究。它是一种 ryanodine 受体调节剂,并通过 ryanodine 受体抑制钙释放。 | |||
T0096 |
Vardenafil
伐地那非,Vivanza,Levitra,Vardenafil hydrochloride |
PDE | Metabolism |
Vardenafil (Vivanza) 是选择性、高效的、具有口服活性的磷酸二酯酶5抑制剂,IC50=0.7 nM。它能够非竞争性地抑制环磷酸鸟苷水解,从而提高 cGMP 水平。它对 PDE1 (180 nM),PDE6 (11 nM),PDE2,PDE3,PDE4 (>1000 nM) 具有选择性。它可用于研究勃起功能障碍。 | |||
T7764 |
CCG-222740
|
ROCK; Rho; Ras | Cell Cycle/Checkpoint; Cytoskeletal Signaling; GPCR/G Protein; MAPK; Stem Cells |
CCG-222740 是一种口服有效的选择性Rho/MRTF 途径抑制剂。它也是 α-平滑肌的肌动蛋白表达抑制剂,可减少皮肤纤维化并阻止黑色素瘤转移。 | |||
T8976 |
PD-089828
|
EGFR; FGFR; PDGFR; Src | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
PD-089828 是受体酪氨酸激酶 FGFR1、PDGFRβ 和 EGFR 的竞争性抑制剂,IC50分别为0.15、1.76 和 5.47 µM。它也是非受体酪氨酸激酶 c-Src 的非竞争性抑制剂,IC50 为 0.18 µM。 | |||
T2176 |
2,3-Butanedione 2-Monoxime
Diacetyl monoxime,2,3-Butanedione-2-monoxime |
Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
2,3-Butanedione 2-Monoxime (Diacetyl monoxime) 是一种肌球蛋白 ATP 酶(myosin ATPase) 抑制剂。它诱导肌质网 Ca2+释放,能够有效抑制骨骼肌和心肌收缩。 | |||
T3461 |
Losartan Carboxylic Acid
EXP-3174,E-3174 |
RAAS | Endocrinology/Hormones |
Losartan Carboxylic Acid (E-3174) 是 Losartan 的活性羧酸代谢产物,是血管紧张素Ⅱ受体 1 型(AT1)拮抗剂。它能够阻断血管紧张素 II 诱导的血管平滑肌细胞反应,可以提高血浆肾素活性,降低平均动脉压。 | |||
T20789 |
S-23
(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide,S23 |
Androgen Receptor | Endocrinology/Hormones |
S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) 是口服选择性雄激素受体调节剂(Ki:1.7 nM)。它能够诱导 CV-1 细胞雄激素受体介导的转录激活,提高去势大鼠前列腺、精囊和肛提肌重量。 | |||
T1487 |
Fluvastatin sodium
XU 62320 sodium,XU-62-320,氟伐他汀钠,Fluvastatin sodium salt |
Ferroptosis; HMG-CoA Reductase; Autophagy | Apoptosis; Autophagy; Metabolism |
Fluvastatin sodium (Fluvastatin sodium salt) salt 是羟甲基戊二酰辅酶 A 还原酶的竞争性抑制剂,IC50为 8 nM。它通过依赖 Nrf2 的抗氧化通路保护血管平滑肌细胞免受氧化应激,是一种常用的降胆固醇剂。 | |||
T1083L |
Theophylline monohydrate
Quibron,茶碱一水合物 |
HDAC; PDE; Adenosine Receptor | Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience |
Theophylline monohydrate (Quibron) 似乎抑制磷酸二酯酶和前列腺素的产生,调节钙通量和细胞内钙分布,并拮抗腺苷。茶碱是黄嘌呤的天然生物碱衍生物,从植物山茶花和小粒咖啡中分离出来。在生理上,该药剂可放松支气管平滑肌,产生血管舒张(脑血管除外),刺激中枢神经系统,刺激心肌,利尿,增加胃酸分泌;它还可以抑制炎症并改善横膈膜的收缩性。 | |||
T1826 |
PI3K-IN-1
Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409 |
DNA-PK; PI3K | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
PI3K-IN-1 (Voxtalisib Analogue) 是 PI3K 抑制剂,PI3K-IN-1(25 μM) 能够阻断 PI3K/Akt 信号通路。 | |||
T4097 |
Vardenafil hydrochloride trihydrate
Vardenafil HCl Trihydrate,BAY38-9456,盐酸瓦地那非三水合物 |
PDE | Metabolism |
Vardenafil hydrochloride trihydrate (BAY38-9456) 是一种新型 PDE 抑制剂,对 PDE5 和 PDE1 的 IC50 分别为 0.7 和 180 nM。 | |||
T4993 |
Afloqualone
氟喹酮,HQ-495 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Afloqualone (HQ-495) 是一种 GABA 受体激动剂。靶点:体外 GABA 受体:Afloqualone 是一种喹唑啉酮家族 GABA 能药物。由于其在 GABAa 受体β亚型的激动剂活性,它具有镇静和肌肉松弛作用。 | |||
T40101 |
(±)-1,2-Diolein
1,2-Dioleoyl-rac-glycerol,甘油1,2-二油酸酯 |
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) 是一种PKC 激活剂,可以增加肌小管 Ca2+内流。 | |||
T4480 |
Vardenafil dihydrochloride
Levitra,Vardenafil Hydrochloride,二盐酸伐地那非 |
PDE | Metabolism |
Vardenafil dihydrochloride (Levitra) 是一种新型 PDE 抑制剂,对 PDE5 和 PDE1 的 IC50 分别为 0.7 和 180 nM。 | |||
T67951 |
JB061
|
Myosin | Cytoskeletal Signaling |
JB061是一种非肌肉肌球蛋白II抑制剂,针对心肌肌球蛋白、骨骼肌肌球蛋白和平滑肌肌球蛋白II的IC50分别为4.4 μM、9.1 μM和>100 μM。其对ATP酶活性的抑制作用较弱(IC50>200 μM)。此外,JB061对COS-7细胞显示出细胞毒性,IC50值为39 μM。 | |||
T67952 |
JB062
|
Myosin | Cytoskeletal Signaling |
JB062是一种针对非肌肉肌球蛋白(nonmusclemyosin)的抑制剂,其IC50值对骨骼肌肌球蛋白为1.6μM、心肌肌球蛋白为5.4μM,而对平滑肌肌球蛋白II大于100μM。此化合物对人类癌细胞显示出细胞毒性,对正常细胞则无此作用。JB062在肌肉痉挛、慢性肌肉骨骼疼痛及肥厚型心肌病研究中有潜在应用价值。 | |||
T21550 |
Blebbistatin
(±)-Blebbistatin |
ATPase; Myosin | Cytoskeletal Signaling; Membrane transporter/Ion channel |
Blebbistatin ((±)-Blebbistatin) 是一种选择性的非肌肉肌球蛋白 II 抑制剂,可促进角膜内皮细胞 (CEC) 的定向迁移并加速伤口愈合,并保留了细胞连接的完整性和屏障功能。 | |||
T1650 |
Chlorzoxazone
Paraflex,Chlorzoxazon,氯唑沙宗 |
P450; Potassium Channel | Membrane transporter/Ion channel; Metabolism |
Chlorzoxazone (Chlorzoxazon) 是作用于中枢的肌肉松弛剂, 可用于肌肉痉挛的研究。 | |||
T0077 |
Dantrolene sodium
Lapatinib ditosylate monohydrate,丹曲林钠,Dantrolene sodium salt |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Dantrolene sodium (Lapatinib ditosylate monohydrate) salt 是一种骨骼肌松弛药,是一种钙通道蛋白抑制剂,可抑制钙离子从肌浆释放。 | |||
T1509 |
Cyclobenzaprine hydrochloride
盐酸环苯扎林,Cyclobenzaprine HCl,MK130 hydrochloride |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Cyclobenzaprine hydrochloride (MK130 hydrochloride) 是一种具有抗抑郁活性的中枢作用肌肉松弛剂,可减少肌肉痉挛。 | |||
T3618 |
GSK-2881078
GSK2881078,GSK 2881078 |
Androgen Receptor | Endocrinology/Hormones |
GSK-2881078 是雄激素受体调节器,可用于精神萎顿的研究。 | |||
T3996 |
Dapiprazole Hydrochloride
盐酸达哌唑,Glamidolo Hydrochloride,Reversil Hydrochloride |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Dapiprazole Hydrochloride (Glamidolo Hydrochloride) 是 α-adrenergic 阻断剂的药物。 | |||
T6618 |
Orphenadrine Citrate
Flexon,Flexoject,Banflex,枸酸芬那君,奥芬那君 |
AChR; iGluR | Membrane transporter/Ion channel; Neuroscience |
Orphenadrine Citrate (Flexon) 是NMDA 受体拮抗剂,Ki 为6.0μM,还是HERG 钾离子通道阻断剂。它是一种骨骼肌松弛剂,它作用于中枢神经系统以产生肌肉松弛作用。 | |||
T0922 |
Zoxazolamine
NSC 24995,Contrazole,氯苯恶唑胺,苯并恶唑胺 |
Others | Others |
Zoxazolamine (NSC-24995) 是排尿酸和肌肉松弛剂,被广泛用于药物测试,可作为啮齿动物细胞色素 P-450 活性变化的方便指标。 | |||
T67911 |
(Iso)-Dehydroemetine
Dehydroisoemetine, (+/-)-,Dehydroisoemetine |
Others | Others |
(Iso)-Dehydroemetine (Dehydroisoemetine, (+/-)-) 是具有平滑肌解痉作用的化合物。 | |||
T7843 |
4-phenoxypiperidine
|
Others | Others |
4-phenoxypiperidine 具有肌肉松弛和抗惊厥活性。 | |||
T4054 |
Dantrolene sodium hemiheptahydrate
Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,丹曲林钠五水合物,Sodium dantrolene |
Calcium Channel; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Dantrolene sodium hemiheptahydrate (Sodium dantrolene) 是一种钙通道蛋白抑制剂, 抑制钙离子从肌浆释放, 它是一种乙内酰脲衍生物和直接作用的骨骼肌松弛剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8242 |
Sabinene
|
Others | Others |
Sabinene 是香料添加剂,具有成为下一代飞机燃料成分的成分。 | |||
T1431 |
Khellin
凯林,Amicardine,Methafrone,Visammin |
EGFR; Others | Angiogenesis; JAK/STAT signaling; Others; Tyrosine Kinase/Adaptors |
Khellin (Methafrone) 是从阿米芹中提取得到的一种呋喃并色酮,是EGFR 抑制剂,IC50为 0.15 µM。它体外具有抗增殖活性,还具有抗痉挛和冠状动脉舒张作用。 | |||
T2S0820 |
Karanjin
干华豆晶 4,水黄皮素 |
Apoptosis; AMPK | Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Karanjin 是干花豆中的主要活性呋喃黄酮醇成分,可通过细胞周期阻滞诱导癌细胞死亡,促进细胞凋亡,还通过提高AMPK 的方式诱导骨骼肌细胞 GLUT4 易位。 | |||
TN1084 |
1,3,5,8-Tetrahydroxyxanthone
Desmethylbellidifolin,去甲基雏叶龙胆酮 |
Anti-infection | Microbiology/Virology |
1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) 是一种天然黄酮,从 Gentianella acuta 中提取得到。它具有镇痉作用和抗炎作用。 | |||
T3S0364 |
L-Arginine
L-精氨酸,L-Arg,(S)-(+)-Arginine |
IL Receptor; Endogenous Metabolite; NO Synthase | Immunology/Inflammation; Metabolism |
L-Arginine (L-Arg) 是内皮型一氧化氮合酶(eNOS) 的底物。L-Arginine 通过阳离子氨基酸转运体家族转运到血管平滑肌细胞,并被代谢成一氧化氮、多胺或 L-脯氨酸。 | |||
T1083 |
Theophylline
Theo-24,1,3-Dimethylxanthine,茶碱 |
Endogenous Metabolite; HDAC; PDE; Adenosine Receptor; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience |
Theophylline (1,3-Dimethylxanthine) 是茶中的甲基黄嘌呤衍生物,具有利尿、平滑肌松弛、支气管扩张、心脏和中枢神经系统兴奋作用。 | |||
T8288 |
14-Deoxyandrographolide
去氧穿心莲内酯,14-去氧穿心莲内酯 |
Apoptosis; Others | Apoptosis; Others |
14-Deoxyandrographolide 是穿心莲中的一种天然产物,是一种钙通道阻断剂,具有保肝功效。它通过诱导 TNFRSF1A 的释放,使肝细胞对 TNF-α 介导的凋亡脱敏。 | |||
T2S1464 |
Thiocolchicoside
硫秋水仙苷;噻可撒可,Thiocolchicine 2-glucoside analog,硫秋水仙苷,Coltramyl |
Others; GABA Receptor | Membrane transporter/Ion channel; Neuroscience; Others |
Thiocolchicoside (Thiocolchicine 2-glucoside analog) 是秋水仙碱的半合成硫衍生物,是竞争性 GABAA 受体拮抗剂和甘氨酸受体拮抗剂。它是肌肉松弛剂,具有抗炎作用,可用于缓解疼痛的研究。 | |||
T2207 |
Adrenosterone
肾上腺甾酮,11-ketoandrostenedione,11-oxoandrostenedione,Reichstein's substance G |
Androgen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Adrenosterone (11-ketoandrostenedione) 是一种人内源性代谢物,由肾上腺皮质产生。Adrenosterone 是一种竞争性羟基类固醇脱氢酶 1 抑制剂。它是一种的类固醇激素,具有较弱的雄激素特性。它是一种膳食补充剂,能够减少脂肪并提高肌肉质量。它能够抑制人类癌细胞的转移进展。 | |||
T6060 |
(±) Anabasine
八角枫碱 |
Endogenous Metabolite | Metabolism |
(±) Anabasine 是肌肉松弛剂,能够用于外科手术时肌肉松驰。 | |||
TN1248 |
3-Epioleanolic acid
|
AChR | Neuroscience |
3-Epioleanolic acid 是一种分离自马鞭草的有效成分,具有抗炎作用。 | |||
T8178 |
Acetagastrodin
乙酰天麻素,Acegastrodine |
Others | Others |
Acetagastrodin (Acegastrodine) 是一种抗氧化剂,也是合成 DBPG 的中间体。 | |||
T38022 |
2,6-Dibromophenol
2,6-Dibromo-phenol,2,6-二溴苯酚 |
Endogenous Metabolite | Metabolism |
2,6-Dibromophenol (2,6-Dibromo-phenol) 从比目鱼的皮肤和肌肉中提取。 | |||
T5294 |
(S)-Leucic acid
L-alpha-羟基异己酸,L-LEUCIC ACID,Hydroxyisocaproic acid,(S)-2-羟基-4-甲基戊酸,(S)-(−)-2-Hydroxyisocaproic acid |
Others; Endogenous Metabolite | Metabolism; Others |
(S)-Leucic acid (Hydroxyisocaproic acid) 是氨基酸代谢物。 | |||
T4888 |
Phosphocreatine disodium hydrate
磷酸肌酸二钠盐,Phosphocreatine disodium salt hydrate |
Others; Endogenous Metabolite | Metabolism; Others |
Phosphocreatine disodium hydrate 是内源性代谢产物的一种。 | |||
T2520 |
Desloratadine
Sch34117,地氯雷他定,NSC 675447 |
Endogenous Metabolite; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Desloratadine (Sch34117) 是非镇静H1抗组胺药 Loratadine 的主要口服代谢物,可减少对支气管平滑肌、毛细血管和胃肠道平滑肌中 H1 受体的典型组胺能作用,包括血管舒张、支气管收缩、血管通透性增加、疼痛、瘙痒和胃肠道平滑肌的痉挛性收缩。它是一种选择性H1受体拮抗剂,具有抗过敏和抗炎活性。 | |||
T3A2467 |
Allocryptopine
Thalictrimine,Fagarine I,别隐品碱 |
Potassium Channel | Membrane transporter/Ion channel |
Allocryptopine (Thalictrimine) 是一种延胡索乙素的衍生物,提取自Corydalis decumbens。Allocryptopine 具有抗心律失常作用,能有效阻断hERG 电流。 | |||
T4592 |
TOMATIDINE HYDROCHLORIDE
Tomatidine,Tomatidine HCl,盐酸番茄碱 |
Others; NF-κB; JNK; Autophagy | Autophagy; MAPK; NF-κB; Others |
Tomatidine hydrochloride (Tomatidine HCl) 是一种甾体生物碱,可防止肌肉萎缩并促进肌肉生长。它通过阻断 NF-κB 和JNK 信号发挥抗炎作用,可激活哺乳动物细胞或秀丽隐杆线虫中的自噬。 | |||
TN1819 |
Kaempferol 3-neohesperidoside
Kaempferol 3-O-neohesperidoside,堪非醇 3-新橙皮糖苷 |
GSK-3; MEK; PI3K | MAPK; PI3K/Akt/mTOR signaling; Stem Cells |
Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) 是一种类黄酮,对大鼠比目鱼肌具有拟胰岛素作用。 | |||
T22300 |
Creatine monohydrate
Methylguanidoacetic acid monohydrate,一水肌酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Creatine monohydrate (Methylguanidoacetic acid monohydrate) 是磷酸原能量系统的关键参与者,尤其是在肌肉和大脑中。 Creatine monohydrate 是高强度、短期活动中 ATP 的主要来源。 | |||
TN1683 |
Gentisin
龙胆根素,龍膽根素 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Gentisin 是一种提取于 Gentianae radix (Gentianaceae) 的天然化合物,具有诱变活性。 | |||
T3O2749 |
L-Leucine
(S)-Leucine,Leu,L-亮氨酸,亮氨酸 |
mTOR | PI3K/Akt/mTOR signaling |
L-Leucine ((S)-Leucine) 是必需的支链氨基酸,能够激活 mTOR 信号通路。 | |||
T5S1408 |
Pteryxin
北美芹素,(+)-Pteryxin |
Others; AChE | Neuroscience; Others |
Pteryxin ((+)-Pteryxin) 是一种白花前胡叶中的香豆素,是一种有效的丁酰胆碱酯酶(BChE)抑制剂,IC50=12.96 μg/ml,具有抗肥胖作用。 | |||
T0496 |
Creatinine
肌酸酐,NSC13123 |
Endogenous Metabolite | Metabolism |
Creatinine (NSC-13123) 由肌肉中磷酸肌酸分解产生。 | |||
T4765 |
L-Norleucine
(S)-Norleucine,alpha-Aminocaproic acid,(S)-2-Aminohexanoic acid,L-2-氨基己酸 |
Influenza Virus; Endogenous Metabolite | Metabolism; Microbiology/Virology |
L-Norleucine ((S)-Norleucine) 是亮氨酸的异构体,特异性影响骨骼肌中的蛋白质合成,具有抗病毒活性。 | |||
T8771 |
Pongamol
|
Others | Others |
Pongamol 是一种从 Pongamia pinnata 果实中鉴定出的铅分子,对骨骼肌细胞的葡萄糖摄取和 GLUT4 易位。 | |||
T15716 |
Lasalocid sodium
拉沙洛西钠,拉沙里菌素,Ionophore X-537A sodium,Antibiotic X-537A sodium,Lasalocid-A sodium |
Antibacterial; Antibiotic; Autophagy | Autophagy; Microbiology/Virology |
Lasalocid sodium (Lasalocid-A sodium) 是一种抗菌剂。 | |||
T7912 |
(−)-Myrtenal
(1R)-(-)-桃金娘烯醛,桃金娘烯醛,(1R)-(−)-Myrtenal |
Others | Others |
(−)-Myrtenal 是一种具有口服活性及抗肿瘤活性的萜烯。(-)-Myrtenal 作用于糖尿病大鼠的骨骼肌和肝脏,利用 Akt 增强 GLUT2 ,进而改善高血糖症。 | |||
T4732 |
L-Carnosine
Karnozin,L-肌肽,beta-Alanyl-L-histidine |
Antioxidant; Endogenous Metabolite | Metabolism; oxidation-reduction |
L-Carnosine (Karnozin) 是 由beta-丙氨酸和组氨酸组成的二肽,具有抑制衰老的作用。 | |||
T0739 |
Guaifenesin
Glycerol guaiacolate,Guaiacol glyceryl ether,愈创甘油醚,Guaiphenesin |
Others | Others |
Guaifenesin (Guaiphenesin) 是一种祛痰剂,来自于 Guajacum officinale Linné 木材中。它可以增加痰液体积和降低其粘度,缓解咳嗽不适,促进有效的咳嗽。 | |||
T4333 |
Quinine dihydrochloride
盐酸奎宁,Quinine bimuriate |
Others | Others |
Quinine dihydrochloride (Quinine bimuriate) 是Cinchona(Rubiaceae) 各种物种的主要生物碱。它也是一种抗疟药和肌肉松弛剂(骨骼)。 | |||
T2O2776 |
L-Valine
|
Others; Endogenous Metabolite | Metabolism; Others |
L-Valine 是蛋白二十种氨基酸中的其中一种。它是必需氨基酸。 | |||
T2917 |
Tetrahydropalmatine hydrochloride
延胡索乙素盐酸盐,1-Tetrahydropalmitine HCl,Gindarine hydrochloride,盐酸延胡乙素 |
Others; Dopamine Receptor | GPCR/G Protein; Neuroscience; Others |
Tetrahydropalmatine hydrochloride (Gindarine hydrochloride) 通过抑制大鼠杏仁核的多巴胺释放来抑制癫痫发作,可用于缓解疼痛的研究。 | |||
T4934 |
1-Methyl-L-histidine
1-甲基-L-组氨酸,3-(1-Methylimidazol-4-yl)-L-alanine,Nτ-Methyl-L-histidine |
Endogenous Metabolite | Metabolism |
1-Methyl-L-histidine (3-(1-Methylimidazol-4-yl)-L-alanine),一种人内源性代谢物,是肉类和外源性 3-methylhistidine 摄入的客观生物标记。 | |||
T0743 |
DL-Carnitine
Carnitina,Carnitine,卡尼丁 |
Others | Others |
DL-Carnitine (Carnitina) 是肝脏和横纹肌的成分。在治疗上它用于刺激胰腺和胃的分泌并治疗高脂蛋白血症。 | |||
T3805 |
Prim-O-glucosylcimifugin
升麻苷,Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside |
TNF; COX; JAK; NO Synthase | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells |
Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) 具有强效的抗炎作用。通过调节 JAK2/STAT3 信号传导可抑制iNOS 和COX-2表达。 | |||
T6S1418 |
Praeruptorin C
|
Antioxidant; Calcium Channel | Membrane transporter/Ion channel; Metabolism; oxidation-reduction |
Praeruptorin C 是白花前胡中的一种主要成分,是钙拮抗剂,pD2′值为 5.7。 | |||
T3262 |
Phosphocreatine disodium
Disodium phosphocreatine,Phosphocreatine disodium salt,Creatine phosphate disodium salt,磷酸肌酸钠 |
Others; Endogenous Metabolite | Metabolism; Others |
Phosphocreatine disodium (Phosphocreatine disodium salt) 是一种磷酸化的肌酸分子,在肌肉、骨骼和大脑中作为一种可快速动员的高能磷酸盐储备。 | |||
T4842 |
1H-pyrazole
1,2-Diazole,Pyrazole,吡唑 |
Others; Endogenous Metabolite | Metabolism; Others |
1H-pyrazole (1,2-Diazole) 是内源性代谢产物的一种。 | |||
T2203 |
D-Carnitine hydrochloride
(S)-Carnitine Hydrochloride,L-Carnitine hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
D-Carnitine hydrochloride ((S)-Carnitine Hydrochloride) 已被用于研究麦角硫因素转运蛋白 SLC22A4 和肉毒碱转运蛋白 SLC22A5,也被用于使棕榈酸进入线粒体。 | |||
T20604L |
Litorin acetate(55749-97-8 Free base)
|
Bombesin Receptor | GPCR/G Protein |
Litorin acetate 是一种两栖类铃蟾肽衍生物,是一种铃蟾肽受体激动剂。它刺激平滑肌收缩,刺激胃泌素、胃酸和胰腺分泌,抑制体内营养。 | |||
T6S2025 |
8-O-Acetylharpagide
8-O-乙酰哈巴苷,8-Acetylharpagide,3-Acetylharpagide,Acetylharpagide,8-O-Acetylharpagide |
Antibacterial | Microbiology/Virology |
8-O-Acetylharpagide 是从 Ajuga reptans 中分离得到的一种环烯醚萜,有抗肿瘤、抗病毒、抗菌和抗炎作用。它对豚鼠的离体平滑肌有生物活性。 | |||
T3S0195 |
Nootkatone
诺卡酮,努特卡酮,诺卡酮 |
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Nootkatone 是一种神经保护剂,来自于Alpiniae OxyphyllaeFructus ,具有抗氧化和抗炎活性。它能够改善脂多糖诱导的阿尔茨海默氏病小鼠模型的认知障碍。 | |||
T0965 |
Histamine
Ergamine,组胺 |
5-HT Receptor; Endogenous Metabolite; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Histamine (Ergamine) 是通过组胺的酶促脱羧衍生的胺。它是一种强大的胃分泌兴奋剂、支气管平滑肌的收缩剂、血管扩张剂以及中枢作用的神经递质。 | |||
PDK0014 |
3-Methylxanthine
|
Endogenous Metabolite | Metabolism |
3-Methylxanthine 是一种黄嘌呤衍生物和环磷酸鸟苷(GMP)抑制剂,在豚鼠分离的气管肌肉中测得其IC50值为 920 μM。 | |||
T5014 |
Prostaglandin E2
地诺前列酮,前列腺素 E2,PGE2,Dinoprostone,Prostaglandin E2 (PGE2) |
Endogenous Metabolite; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism |
Prostaglandin E2 (PGE2) 是一种天然激素,参与人体内的各种生理过程,包括平滑肌收缩和放松、调节血管扩张和收缩、调节血压和炎症调节。 | |||
T6534 |
Histamine dihydrochloride
组胺二盐酸盐,peremin,Ceplene,Histamine 2HCl |
Endogenous Metabolite; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Histamine dihydrochloride (Ceplene) 是 Histamine 的二盐酸形式。Histamine 是一种有机氮化合物,是一种强效的胃分泌兴奋剂,支气管平滑肌收缩剂,血管舒张剂,也是一种中枢作用的神经递质。 | |||
T6102 |
2'-acetylacteoside
|
Antioxidant; Reductase | Endocrinology/Hormones; Metabolism; oxidation-reduction |
2'-Acetylacteoside 是一种苯乙醇苷类化合物,分离自来江藤中,可抑制自由基诱导的红细胞溶血,具有清除自由基的作用。 | |||
T3232 |
Higenamine hydrochloride
Higenamine HCl,Demethylcoclaurine hydrochloride,盐酸去甲乌头碱,norcoclaurine HCl,(+-)-Demethylcoclaurine hydrochloride,Higenamine Hydrochloride |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Higenamine hydrochloride (norcoclaurine HCl) 是一种 β2-AR 激动剂,是用于心力衰竭相关研究的中药乌头的关键成分,具有抗凋亡活性。 | |||
T5059 |
L-Tartaric acid
L-酒石酸,L(+)-Tartaric acid,(2R,3R)-(+)-Tartaric acid |
Antioxidant; Endogenous Metabolite | Metabolism; oxidation-reduction |
L-Tartaric acid ((2R,3R)-(+)-Tartaric acid) 是内源性代谢产物的一种。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03446 |
ENO3 Protein, Human, Recombinant (His)
enolase 3 (beta, muscle),GSD13,MSE,enolase 3 (β, |
Human | E. coli |
ENO3 is one of the three enolase isoenzymes found in mammals. As a homodimer, ENO3 is found in skeletal muscle cells in the adult. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in ENO3 gene can be associated with metabolic myopathies that may result from decreased stability of the enzyme. Two transcripts have been identified for ENO3 gene that differ only in their 5' UTR. ENO3 may play a role in muscle development and regenera... | |||
TMPY-02499 |
Cofilin 2 Protein, Human, Recombinant (His)
cofilin 2 (muscle),NEM7 |
Human | E. coli |
Cofilin 2 (muscle), also known as CFL2, is a member of cofilin family of the actin-binding protein superfamily. Cofilin2 shows significant homology to the other two members: cofilin 1 and DSTN, through its entire sequence, and contains residues conserved among the cofilin family that are responsible for actin-binding. Cofilin 2 (CFL2) is an important regulator of striated myocyte function. Purified cofilin 2 depolymerized actin filaments in a dose- and pH-dependent manner and reduced the apparen... | |||
TMPY-01027 |
Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His)
carnitine palmitoyltransferase 1B (muscle),AV080368... |
Mouse | HEK293 Cells |
Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. It is a 226 amino acid (aa) protein that has a conserved pattern of six cysteines and one potential glycosylation site. The granule-derived mouse mast cell proteases-1 and -2 (mMCP-1 and -2) colocalize in similar quantities in mucosal mast cells but micrograms of mMCP-1 compared w... | |||
TMPY-04557 |
PHKG1 Protein, Human, Recombinant (GST)
phosphorylase kinase, γ 1 (muscle),phosphorylase ki... |
Human | Baculovirus Insect Cells |
Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform, also known as Phosphorylase kinase subunit gamma-1 and PHKG1, is a member of the protein kinase superfamily and CAMK Ser/Thr protein kinase family. PHKG1 is the catalytic member of a 16 subunit protein kinase complex that contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. Muscle glycogenosis caused by phosphorylase kinase (Phk) deficiency may lead to exercise intolerance, ... | |||
TMPY-04762 |
CKM Protein, Human, Recombinant (His)
creatine kinase, muscle,M-CK,CKMM |
Human | E. coli |
CKM, also known as CK-MM, is mainly expressed in skeletal muscle. As the primary CK isoenzyme, it also can be detected in heart muscle. CKM is a subunit of creatine kinase (CK). CK is an enzyme expressed by various tissues and cell types. It catalyses the conversion of creatine and consumes adenosine triphosphate (ATP) to create phosphocreatine and adenosine diphosphate (ADP). In the cells, the cytosolic CK enzymes consist of two subunits, which can be either B (brain type) or M (muscle type). | |||
TMPY-02298 |
ACYP2 Protein, Human, Recombinant (GST)
ACYM,acylphosphatase 2, muscle type,ACYP |
Human | E. coli |
Recent genome-wide association studies have identified genetic variants in ACYP2 and WFS1 that are associated with cisplatin-induced ototoxicity. We sought to explore the role of these genetic susceptibility factors to cisplatin-induced ototoxicity in patients with testicular cancer. Telomere length, as a marker of biological aging, has been reported to influence the risk of several age-related diseases, including ischemic stroke. Recent studies have identified the genetic variant within ACYP2 a... | |||
TMPY-04414 |
MUSK Protein, Human, Recombinant (aa 433-783, His & GST)
FADS,CMS9,muscle, skeletal, receptor tyrosine kinas... |
Human | Baculovirus Insect Cells |
Muscle, skeletal receptor tyrosine-protein kinase, also known as Muscle-specific tyrosine-protein kinase receptor, Muscle-specific kinase receptor, and MUSK, is a single-pass type I membrane protein that belongs to the protein kinase superfamily and tyr protein kinase family. MUSK contains one FZ (frizzled) domain, three Ig-like C2-type (immunoglobulin-like) domains, and one protein kinase domain. This protein is a muscle-specific tyrosine kinase receptor and it may play a role in clustering of ... | |||
TMPY-03607 |
Cofilin Protein, Human, Recombinant (His)
CFL,HEL-S-15,cofilin 1 (non-muscle) |
Human | E. coli |
CFL1, also known as n-cofilin, is a member of the ADF/Cofilin family. This family comprises three genes: CFL1, CFL2 and DSTN (destrin). ADF/Cofilin family members bind G-actin monomers and depolymerize actin filaments through two mechanisms: severing and increasing the off-rate for actin monomers from the pointed end. Cofilin also binds with other proteins such as myosin, tropomyosin, α-actinin, gelsolin and scruin. These proteins compete with cofilin for actin binding. Сofilin also plays a... | |||
TMPH-02547 |
ENO3 Protein, Mouse, Recombinant (His & Myc)
Skeletal muscle enolase,Eno3,Enolase 3,2-phospho-D-... |
Mouse | E. coli |
Appears to have a function in striated muscle development and regeneration. ENO3 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 54.3 kDa and the accession number is P21550. | |||
TMPY-04479 |
PFKM Protein, Human, Recombinant (His & GST)
ATP-PFK,PFK-1,PFK1,PFKA,PFKX,GSD7,phosphofructokinase, m... |
Human | Baculovirus Insect Cells |
PFK1, also known as PFKM, is a regulatory glycolytic enzyme. PFK1 converts fructose 6-phosphate and ATP into fructose 1,6-bisphosphate (through PFK-1), fructose 2,6-bisphosphate (through PFK-2) and ADP. It is a muscle-type isozyme. There are three phosphofructokinase isozymes in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Mutations i... | |||
TMPH-02546 |
ENO3 Protein, Mouse, Recombinant (His)
Eno3,Beta-enolase,Skeletal muscle enolase,Muscl... |
Mouse | P. pastoris (Yeast) |
Appears to have a function in striated muscle development and regeneration. | |||
TMPH-00881 |
ACTA1 Protein, Human, Recombinant (His)
Actin, alpha skeletal muscle,Alpha-actin-1 |
Human | E. coli |
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. ACTA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 45.8 kDa and the accession number is P68133. | |||
TMPY-03438 |
Calsequestrin 1 Protein, Human, Recombinant
CASQ,PDIB1,VMCQA,calsequestrin 1 (fast-twitch, skeletal ... |
Human | E. coli |
Calsequestrin-1 is an isoform of calsequestrin. Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. It helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol. Two forms of calsequestrin have been identified: Calsequestrin-2 and Calsequestrin-1. Calsequestrin-1 is found in fast skeletal muscle. The release of calsequestrin-boun... | |||
TMPH-01032 |
Calponin-2/CNN2 Protein, Human, Recombinant (His & SUMO)
Calponin-2,Calponin H2, smooth muscle,Neutral calpo... |
Human | E. coli |
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. Calponin-2/CNN2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 49.6 kDa and the accession number is Q99439. | |||
TMPY-04465 |
PKM2 Protein, Human, Recombinant (His)
pyruvate kinase, muscle,OIP3,CTHBP,PK3,THBP1,HEL-S-... |
Human | E. coli |
PKM2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 59 kDa and the accession number is P14618-1. | |||
TMPY-02223 |
GSTM2 Protein, Human, Recombinant (His)
GSTM2-2,GTHMUS,glutathione S-transferase mu 2 (muscle |
Human | E. coli |
Glutathione S-transferase Mu 2, also known as GST class-mu 2, GSTM2-2, and GSTM2, is a cytoplasm protein that belongs to the GST superfamily and Mu family. GSTM2 / GST4 contains one GST C-terminal domain and one GST N-terminal domain. The glutathione S-transferases (GSTs) are a multigene family of enzymes largely involved in the detoxification of chemicals. Eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, si... | |||
TMPH-02663 |
Aldolase A Protein, Mouse, Recombinant (His & Myc)
Aldoa,Aldolase 1,Fructose-bisphosphate aldolase A,Aldo1,... |
Mouse | E. coli |
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. Aldolase A Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 46.7 kDa and the accession number is P05064. | |||
TMPH-02662 |
Aldolase A Protein, Mouse, Recombinant (His)
Aldolase 1,Fructose-bisphosphate aldolase A,Muscle-... |
Mouse | Baculovirus Insect Cells |
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. Aldolase A Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 40.3 kDa and the accession number is P05064. | |||
TMPY-04766 |
PKM2 Protein, Mouse, Recombinant (His)
AL024424,AA414905,Pk3,Pk-3,pyruvate kinase, muscle,... |
Mouse | Baculovirus Insect Cells |
PKM2 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 60 kDa and the accession number is P52480-2. | |||
TMPJ-00384 |
PFKM Protein, Human, Recombinant (His)
Phosphofructo-1-kinase isozyme A,Phosphohexokinase,PFKX,6-ph... |
Human | HEK293 Cells |
6-phosphofructokinase, muscle type is a muscle-type isozyme that in humans is encoded by the PFKM gene. It belongs to the phosphofructokinase family and Two domains subfamily. PFKM functions as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. PFK1 converts fructose 6-phosphate and ATP into fructose 1,6-bisphosphate (through PFK-1), fructose 2,6-bisphosphate (through PFK-2) and ADP. | |||
TMPH-00882 |
ACTA2 Protein, Human, Recombinant (His)
Alpha-actin-2,Actin, aortic smooth muscle,Cell grow... |
Human | E. coli |
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. ACTA2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 47.8 kDa and the accession number is P62736. | |||
TMPH-01210 |
DENR Protein, Human, Recombinant (His & SUMO)
DRP,Smooth muscle cell-associated protein 3,DENR,De... |
Human | E. coli |
DENR Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 38.0 kDa and the accession number is O43583. | |||
TMPH-01357 |
ALDOA Protein, Human, Recombinant (His)
Muscle-type aldolase,Lung cancer antigen NY-LU-1,Fr... |
Human | E. coli |
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. ALDOA Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 45.3 kDa and the accession number is P04075. | |||
TMPJ-00696 |
NOL3 Protein, Human, Recombinant
Apoptosis Repressor With CARD,Nucleolar Protein of 30 kDa,Nu... |
Human | E. coli |
Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. It inhibits extrinsic apoptotic pathways through two different ways. Firstly, it by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex ... | |||
TMPJ-00697 |
NOL3 Protein, Human, Recombinant (GST)
Nop30,Myp,NOP,Apoptosis Repressor With CARD,Nucleolar Protei... |
Human | E. coli |
Nucleolar Protein 3 is encoded by NOL3 gene; multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing.Isoform 2 may inhibit apoptosis.It has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. | |||
TMPJ-00724 |
LDHA Protein, Human, Recombinant (His)
LDH-M,Renal Carcinoma Antigen NY-REN-59,Cell Proliferation-I... |
Human | E. coli |
L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region, a central catalytic site, and at least nine utilized Lys acetylation and two Tyr phosphorylation sites. LDHA belongs to the lactate dehydrogenase family, expressed predominantly in muscle tissue. LDHA mutations have been linked to exertional myoglobinuria. | |||
TMPH-01176 |
CSRP3 Protein, Human, Recombinant (His & SUMO)
CLP,CRP,Muscle LIM protein,CSRP3,Cardiac LIM protei... |
Human | E. coli |
CSRP3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-00780 |
CACNA1C Protein, Guinea Pig, Recombinant (His)
CACNA1C,CACNL1A1,CACH2,CACN2,Voltage-dependent L-type calciu... |
Guinea pig | E. coli |
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressur... | |||
TMPY-04826 |
LILRB5/CD85c Protein, Human, Recombinant (His)
leukocyte immunoglobulin like receptor B5,LIR8,LIR-8,CD85C |
Human | HEK293 Cells |
A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. LILRB5/CD85c Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weig... | |||
TMPJ-01210 |
IL-33 Protein, Mouse, Recombinant
Interleukin-1 family member 11,白细胞介素,NF-HEV and IL- 1F11,白介素... |
Mouse | E. coli |
Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produ... | |||
TMPY-05030 |
PCDH7 Protein, Human, Recombinant (His)
BHPCDH |
Human | Baculovirus Insect Cells |
PCDH7, a member of protocadherins family, functions as tumor suppressor in several human cancers. The human PCDH7 gene is localized in chromosome 4p15, which is often inactivated in human cancers, including bladder cancer. The low PCDH7 expression is a potential prognostic biomarker for primary non-muscle invasive bladder cancer (NMIBC). PCDH7 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 94 kDa and the accession number... | |||
TMPY-03382 |
FGF-6 Protein, Human, Recombinant
HBGF-6,HST2,fibroblast growth factor 6 |
Human | E. coli |
FGF6, also known as FGF-6, belongs to the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF6 plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis. It is also required for normal muscle regeneration. FGF6 gene d... | |||
TMPJ-00261 |
TGF beta 2 Protein, Mouse/Rat, Recombinant
transforming growth factor β-2,BSC-1 cell growth inhibitor,G... |
Mouse,Rat | HEK293 Cells |
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the n... | |||
TMPJ-00562 |
PDGF-BB Protein, Mouse, Recombinant (His)
PDGFBB,PDGF-BB,血小板源生长因子 |
Mouse | E. coli |
Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. As growth factor,it plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival... | |||
TMPJ-00662 |
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)
Receptor activator of nuclear factor kappa-B ligand,Receptor... |
Human | E. coli |
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitog... | |||
TMPY-05004 |
FGF-4 Protein, Human, Recombinant
HST-1,KFGF,fibroblast growth factor 4,HSTF1,K-FGF,HST,HBGF-4 |
Human | E. coli |
FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specification of both blood and skeletal muscle lineages. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from embryonic stem cells (ESCs) via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) a... | |||
TMPY-05510 |
BDNF Protein, Mouse, Recombinant (His)
brain-derived neurotrophic factor |
Mouse | HEK293 Cells |
BDNF is a member of thenerve growth factorfamily. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth,... | |||
TMPJ-00071 |
EPO/Erythropoietin Protein, Human, Recombinant (His)
Erythropoietin,EPO,红细胞生长素,Epoetin |
Human | HEK293 Cells |
Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoietin is a member of the EPO/TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EP... | |||
TMPJ-01065 |
Noggin/NOG Protein, Mouse, Recombinant (His)
Nog,Noggin |
Mouse | HEK293 Cells |
Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs). Mouse Noggin cDNA encodes a 232 amino acid (aa) residue precursor protein with 19 aa residue putative signal peptide that is cleaved to generate the 213 aa residue mature protein which is secreted as a homodimeric glycoprotein. Secreted Noggin probably remains close to the cell surface due to its binding of heparin-containing proteoglycans. Noggin binds some BMPs such as BMP4 with high affi... | |||
TMPY-01085 |
VLDLR Protein, Human, Recombinant (His)
VLDLRCH,CAMRQ1,CHRMQ1,very low density lipoprotein receptor,... |
Human | HEK293 Cells |
The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and ApoER2, and is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar sdomain. VLDLR contains 3 EGF-like domains, 8 LDL-receptor class A domains, as well as 6 LDL-receptor class B repeats, and is ... | |||
TMPY-04552 |
AKT1 Protein, Human, Recombinant (His)
RAC-ALPHA,v-akt murine thymoma viral oncogene homolog 1,RAC,... |
Human | Baculovirus Insect Cells |
v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. AKT1 activity is required for physiologic cardiac growth in response to IGF1 stimulation or exercise training. In contrast, AKT1 ac... | |||
TMPH-02253 |
TPM2 Protein, Human, Recombinant (His)
|
Human | E. coli |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. | |||
TMPH-02252 |
TPM3 Protein, Human, Recombinant (GST)
|
Human | E. coli |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. | |||
TMPH-03213 |
TPM1 Protein, Rabbit, Recombinant (E. coli, His & Myc)
|
Rabbit | E. coli |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. TPM1 Protein, Rabbit, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular w... | |||
TMPH-03212 |
TPM1 Protein, Rabbit, Recombinant (His & Myc)
|
Rabbit | Baculovirus Insect Cells |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. TPM1 Protein, Rabbit, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 3... | |||
TMPH-03282 |
TRIM63 Protein, Rat, Recombinant (His & Myc)
|
Rat | E. coli |
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate... | |||
TMPH-02634 |
TRIM63 Protein, Mouse, Recombinant (His & Myc)
|
Mouse | E. coli |
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate... | |||
TMPY-03984 |
TPM1 Protein, Human, Recombinant (His)
TMSA,tropomyosin 1 (alpha),LVNC9,CMH3,HTM-alpha,CMD1Y,C15orf... |
Human | E. coli |
TPM1, also known as tropomyosin-1, is a member of the tropomyosin family. Members of this family are highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. TPM1 is one type of alpha-helical chain that forms the predomin... | |||
TMPH-01271 |
TRIM63 Protein, Human, Recombinant (His & Myc)
|
Human | E. coli |
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate... | |||
TMPY-03600 |
TPM4 Protein, Human, Recombinant (His)
tropomyosin 4,HEL-S-108,TPM4 |
Human | HEK293 Cells |
TPM4, also known as tropomyosin 4, is a member of the tropomyosin family. Members of this family are actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. TPM4 is expressed in cardiac tissue and platelets. It is highly expressed in the platelets of hypertensive patients. TPM4 plays a central role, in association with the troponin complex, in the calcium-dependent regulation of vertebrate striated muscle contraction. Smo... | |||
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