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PFKFB3 Protein, Human, Recombinant (His)

PFKFB3 Protein, Human, Recombinant (His)

产品编号 TMPJ-00319
别名: PFK/FBPase 3, PFK2, IPFK2, iPFK-2

Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis. Highly phosphorylated PFKFB3 protein was found in human tumor cells, vascular endothelial cells, and smooth muscle cells. Because of its proto-oncogenic character, the PFK-2/FBPase-2 of the PFKFB3 gene is assumed to play a critical role in tumorigenesis. PFKFB3 also plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways even under severe hypoxic conditions, which makes it a potential target for cancer therapy.

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PFKFB3 Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
10 μg ¥ 750 5日内发货
50 μg ¥ 2,260 5日内发货
500 μg ¥ 12,100 5日内发货
1 mg ¥ 18,300 5日内发货
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产品目录号及名称: PFKFB3 Protein, Human, Recombinant (His) (TMPJ-00319)
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产品描述 Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis. Highly phosphorylated PFKFB3 protein was found in human tumor cells, vascular endothelial cells, and smooth muscle cells. Because of its proto-oncogenic character, the PFK-2/FBPase-2 of the PFKFB3 gene is assumed to play a critical role in tumorigenesis. PFKFB3 also plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways even under severe hypoxic conditions, which makes it a potential target for cancer therapy.
种属 Human
表达系统 E. coli
标签 N-6xHis
蛋白编号 Q16875
别名 PFK/FBPase 3, PFK2, IPFK2, iPFK-2
氨基酸序列 Met1-His520
蛋白构建 Met1-His520
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 57-62 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Supplied as a 0.2 μm filtered solution of 20 mM PB, 50 mM KCl, 5 mM DTT, 0.1 mM EDTA, 50% glycerol, 0.1% TritonX-100, pH 6.0.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis. Highly phosphorylated PFKFB3 protein was found in human tumor cells, vascular endothelial cells, and smooth muscle cells. Because of its proto-oncogenic character, the PFK-2/FBPase-2 of the PFKFB3 gene is assumed to play a critical role in tumorigenesis. PFKFB3 also plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways even under severe hypoxic conditions, which makes it a potential target for cancer therapy.

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Keywords

PFKFB3 Protein, Human, Recombinant (His) PFK/FBPase 3 IPFK 2 PFK2 PFK-2 IPFK2 PFK 2 iPFK-2 recombinant recombinant-proteins proteins protein

 

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