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proHB-EGF Protein, Human, Recombinant (His)

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货号 TMPJ-01286

别名 proheparin-binding EGF-like growth factor, pro HB-EGF, heparin-binding epidermal growth factor, heparin-binding EGF-like growth factor, HEGFL, HB-EGF, DTSF, DTS, DTR, Diphtheria toxin receptor

Heparin-binding EGF-like growth factor (HB-EGF) is a 12­16 kDa member of the epidermal growth factor (EGF) family. It possesses an EGF­like domain, and a heparin-binding motif. Mature HB­EGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HB­EGF shows 76% and 73% aa sequence identity with rat and mouse HB­EGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation; it is mitogenic for fibroblasts, but not endothelial cells. HB­EGF classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activity associated with ErbB4 binding appears to be limited to non­mitogenic actions, while EGFR binding induces both mitogenic and non­mitogenic activity.

proHB-EGF Protein, Human, Recombinant (His)
其他形式的 “proHB-EGF Protein, Human, Recombinant (His)”:
DTS
HB-EGF Protein, Human, Recombinant

proHB-EGF Protein, Human, Recombinant (His)

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Rating icon 还可以
SPR兼容缓冲液
货号 TMPJ-01286 别名 proheparin-binding EGF-like growth factor, pro HB-EGF, heparin-binding epidermal growth factor, heparin-binding EGF-like growth factor, HEGFL, HB-EGF, DTSF, DTS, DTR, Diphtheria toxin receptor

Heparin-binding EGF-like growth factor (HB-EGF) is a 12­16 kDa member of the epidermal growth factor (EGF) family. It possesses an EGF­like domain, and a heparin-binding motif. Mature HB­EGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HB­EGF shows 76% and 73% aa sequence identity with rat and mouse HB­EGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation; it is mitogenic for fibroblasts, but not endothelial cells. HB­EGF classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activity associated with ErbB4 binding appears to be limited to non­mitogenic actions, while EGFR binding induces both mitogenic and non­mitogenic activity.

规格价格库存数量
5 μg
¥ 243
6-8日内发货
10 μg
¥ 380
6-8日内发货
20 μg
¥ 546
5日内发货
50 μg
¥ 900
5日内发货
100 μg
¥ 1,450
5日内发货
200 μg
¥ 2,360
5日内发货
500 μg
¥ 4,530
5日内发货
1 mg
¥ 6,520
5日内发货
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产品介绍

生物活性
产品描述
Heparin-binding EGF-like growth factor (HB-EGF) is a 12­16 kDa member of the epidermal growth factor (EGF) family. It possesses an EGF­like domain, and a heparin-binding motif. Mature HB­EGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HB­EGF shows 76% and 73% aa sequence identity with rat and mouse HB­EGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation; it is mitogenic for fibroblasts, but not endothelial cells. HB­EGF classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activity associated with ErbB4 binding appears to be limited to non­mitogenic actions, while EGFR binding induces both mitogenic and non­mitogenic activity.
生物活性
Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
研究背景
Heparin-binding EGF-like growth factor (HB-EGF) is a 12­16 kDa member of the epidermal growth factor (EGF) family. It possesses an EGF­like domain, and a heparin-binding motif. Mature HB­EGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HB­EGF shows 76% and 73% aa sequence identity with rat and mouse HB­EGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation; it is mitogenic for fibroblasts, but not endothelial cells. HB­EGF classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activity associated with ErbB4 binding appears to be limited to non­mitogenic actions, while EGFR binding induces both mitogenic and non­mitogenic activity.
种属
Human
表达系统
HEK293 Cells
标签C-6xHis
蛋白编号Q99075
氨基酸序列Leu20-Leu148
蛋白构建Leu20-Leu148
蛋白纯度
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名proheparin-binding EGF-like growth factor, pro HB-EGF, heparin-binding epidermal growth factor, heparin-binding EGF-like growth factor, HEGFL, HB-EGF, DTSF, DTS, DTR, Diphtheria toxin receptor
内毒素< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
化学信息
分子量16-27 KDa (reducing condition)
储存&溶解度
运输方式In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
存储Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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剂量转换

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