Huwentoxin-IV

Name: Huwentoxin-IV
Brand: TargetMol
SKU: TP2016
Rating: 4.5 (1 reviews)

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产品编号 TP2016Cas号 526224-73-7

别名 Huwentoxin IV

Selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). Inhibits the channel by binding at the neurotoxin receptor site 4 in the S3-S4 linker of domain II, trapping the voltage sensor in the inward, closed configuration.

Huwentoxin-IV

还可以

产品编号 TP2016 别名 Huwentoxin IVCas号 526224-73-7

规格	价格	库存	数量
1 mg	¥ 5,940	待询

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产品介绍

生物活性

产品描述	Selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). Inhibits the channel by binding at the neurotoxin receptor site 4 in the S3-S4 linker of domain II, trapping the voltage sensor in the inward, closed configuration.
靶点活性	Nav1.7:26 nM, Nav1.2:150 nM, Nav1.4:400 nM, Nav1.3:338 nM
别名	Huwentoxin IV

化学信息

分子量	4106.79
分子式	C₁₇₄H₂₇₈N₅₂O₅₁S₆
CAS No.	526224-73-7
密度	no data available
Sequence	Glu-Cys-Leu-Glu-Ile-Phe-Lys-Ala-Cys-Asn-Pro-Ser-Asn-Asp-Gln-Cys-Cys-Lys-Ser-Ser-Lys-Leu-Val-Cys-Ser-Arg-Lys-Thr-Arg-Trp-Cys-Lys-Tyr-Gln-Ile-NH2 (Disulfide bridge:Cys2-Cys17;Cys9-Cys24;Cys16-Cys31)
Sequence Short	ECLEIFKACNPSNDQCCKSSKLVCSRKTRWCKYQI-NH2 (Disulfide bridge:Cys2-Cys17;Cys9-Cys24;Cys16-Cys31)

储存&溶解度

存储	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	H2O: 1 mg/mL (0.24 mM), Sonication is recommended.