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CSRP3 Protein, Human, Recombinant (His & SUMO)

产品编号 TMPH-01176

别名: CLP, CRP, Muscle LIM protein, CSRP3, Cardiac LIM protein, Cysteine-rich protein 3, LIM domain protein, cardiac, MLP, Cysteine and glycine-rich protein 3

CSRP3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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CSRP3 Protein, Human, Recombinant (His & SUMO)

规格	价格/CNY		货期	数量
20 μg	￥ 1,320		20日内发货
100 μg	￥ 2,470		20日内发货
1 mg	￥ 10,700		20日内发货

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产品描述	CSRP3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.

种属	Human
表达系统	E. coli
标签	N-6xHis-SUMO
蛋白编号	P50461
别名	CLP, CRP, Muscle LIM protein, CSRP3, Cardiac LIM protein, Cysteine-rich protein 3, LIM domain protein, cardiac, MLP, Cysteine and glycine-rich protein 3
氨基酸序列	MPNWGGGAKCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRRYGPKGIGYGQGAGCLSTDTGEHLGLQFQQSPKPARSVTTSNPSKFTAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTQQVEKKE
蛋白构建	1-194 aa
蛋白纯度	> 90% as determined by SDS-PAGE.
分子量	37.0 kDa (predicted)

缓冲液	Tris-based buffer, 50% glycerol
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization. Proposed to contribute to the maintenance of muscle cell integerity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association. In vitro can inhibit PKC/PRKCA activity. Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling.; May play a role in early sarcomere organization. Overexpression in myotubes negatively regulates myotube differentiation. By association with isoform 1 and thus changing the CSRP3 isoform 1:CFL2 stoichiometry is proposed to down-regulate CFL2-mediated F-actin depolymerization.

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Keywords

CSRP3 Protein, Human, Recombinant (His & SUMO) CLP CRP Muscle LIM protein CSRP3 Cardiac LIM protein Cysteine-rich protein 3 LIM domain protein, cardiac MLP Cysteine and glycine-rich protein 3 recombinant recombinant-proteins proteins protein

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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