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顶部相关产品产品介绍化学信息储存和溶解信息计算器

20-carboxy Arachidonic Acid

货号 T36232Cas号 79551-84-1 一键复制产品信息
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20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα) (Kd = 0.87 ± 0.12 μM) and PPARγ (Kd = 1.7 ± 0.5 μM), and is a dual activator of PPARα and PPARγ in a transiently transfected COS-7 cell reporter system.

20-carboxy Arachidonic Acid

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货号 T36232Cas号 79551-84-1

20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα) (Kd = 0.87 ± 0.12 μM) and PPARγ (Kd = 1.7 ± 0.5 μM), and is a dual activator of PPARα and PPARγ in a transiently transfected COS-7 cell reporter system.

20-carboxy Arachidonic Acid
规格价格库存数量
25 μg
¥ 5,680
35日内发货
50 μg
¥ 10,700
35日内发货
100 μg
¥ 19,800
35日内发货
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产品介绍

生物活性
产品描述
20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα) (Kd = 0.87 ± 0.12 μM) and PPARγ (Kd = 1.7 ± 0.5 μM), and is a dual activator of PPARα and PPARγ in a transiently transfected COS-7 cell reporter system.
化学信息
分子量334.456
分子式C20H30O4
CAS No.79551-84-1
SmilesOC(=O)CCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
储存&溶解度
存储
溶解度信息
0.1 M Na2CO3: 1.5 mg/mL (4.48 mM), Sonication is recommended.
DMF: 100 mg/mL (298.99 mM), Sonication is recommended.
Ethanol: 100 mg/mL (298.99 mM), Sonication is recommended.
DMSO: 100 mg/mL (298.99 mM), Sonication is recommended.
溶液配制表
0.1 M Na2CO3/DMF/Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.9899 mL14.9496 mL29.8993 mL149.4965 mL
DMF/Ethanol/DMSO
1mg5mg10mg50mg
5 mM0.5980 mL2.9899 mL5.9799 mL29.8993 mL
10 mM0.2990 mL1.4950 mL2.9899 mL14.9496 mL
20 mM0.1495 mL0.7475 mL1.4950 mL7.4748 mL
50 mM0.0598 mL0.2990 mL0.5980 mL2.9899 mL
100 mM0.0299 mL0.1495 mL0.2990 mL1.4950 mL
该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

20-carboxy Arachidonic Acid20carboxy Arachidonic Acid20 carboxy Arachidonic Acid
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