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顶部生物活性储存和溶解信息计算器

Anti-Phospho-PKM (Ser37) Polyclonal Antibody

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Anti-Phospho-PKM (Ser37) Polyclonal Antibody
产品编号 TMAC-03352
别名 THBP1, TCB, pyruvate kinase, muscle, p-PKM2 (Ser37), p-PKM2 (S37), PKM2 (p-Ser37), PKM2 (p-S37), PKM2, PK3, OIP3, HEL-S-30, CTHBP

Anti-Phospho-PKM (Ser37) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-PKM (Ser37)。Anti-Phospho-PKM (Ser37) Polyclonal Antibody 可用于 WB,IF。

Anti-Phospho-PKM (Ser37) Polyclonal Antibody

Anti-Phospho-PKM (Ser37) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-PKM (Ser37) Polyclonal Antibody
产品编号 TMAC-03352 别名 THBP1, TCB, pyruvate kinase, muscle, p-PKM2 (Ser37), p-PKM2 (S37), PKM2 (p-Ser37), PKM2 (p-S37), PKM2, PK3, OIP3, HEL-S-30, CTHBP

Anti-Phospho-PKM (Ser37) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-PKM (Ser37)。Anti-Phospho-PKM (Ser37) Polyclonal Antibody 可用于 WB,IF。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,230
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-PKM (Ser37) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PKM (Ser37). Anti-Phospho-PKM (Ser37) Polyclonal Antibody can be used in WB,IF.
别名THBP1, TCB, pyruvate kinase, muscle, p-PKM2 (Ser37), p-PKM2 (S37), PKM2 (p-Ser37), PKM2 (p-S37), PKM2, PK3, OIP3, HEL-S-30, CTHBP
Ig Type
IgG
交叉反应
Human
验证活性
1. Western blot analysis of in vitro kinase assays carried out with puried active ERK2, wild-type (WT) PKM2 and PKM2 S37A mutant using PKM2 (phospho-Ser37)Antibody TMAC-03352.
2. Immunofluorescence staining of methanol-fixed MEF cells using PKM2 (phospho-Ser37) Antibody TMAC-03352.
应用
WB
IF
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. Weiwei Yang1, Yanhua Zheng1, Yan Xia1, Haitao Ji, "ERK1/2-dependent phosphorylation and nucleartranslocation of PKM2 promotes the Warburg effect." Nature Cell Biology(2012)|doi:10.1038/ncb2629
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of serine 37(I-D-S(p)-P-P) derived from Human PKM2
抗原种属
human
Uniprot ID
P14618
化学信息
分子量Actual: 60 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

  • 稀释 计算器

关键词

THBP-1THBP 1pPKM2 (Ser37)pPKM2 (S37)PKM2 (pSer37)PKM2 (pS37)PKM2 (phospho-Ser37)PKM2 (phospho-S37)PKM-2PKM 2PK-3PK 3OIP-3OIP 3

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