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顶部相关产品产品介绍化学信息储存和溶解信息计算器

16-phenoxy tetranor Prostaglandin F2α methyl ester

Synonyms: 16-phenoxy tetranor Prostaglandin F2α methyl ester
货号 T37937Cas号 51638-90-5 一键复制产品信息
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Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF2α are used to modulate luteolysis and treat glaucoma. 16-phenoxy tetranor Prostaglandin F2α (16-phenoxy tetranor PGF2α) is a metabolically stable form of PGF2α containing a 16-phenoxy group at the ω-terminus. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α. 16-phenoxy tetranor PGF2α methyl ester is a lipophilic analog of 16-phenoxy tetranor PGF2α. Methyl esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid.

16-phenoxy tetranor Prostaglandin F2α methyl ester

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货号 T37937Cas号 51638-90-5

别名 16-phenoxy tetranor Prostaglandin F2α methyl ester

Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF2α are used to modulate luteolysis and treat glaucoma. 16-phenoxy tetranor Prostaglandin F2α (16-phenoxy tetranor PGF2α) is a metabolically stable form of PGF2α containing a 16-phenoxy group at the ω-terminus. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α. 16-phenoxy tetranor PGF2α methyl ester is a lipophilic analog of 16-phenoxy tetranor PGF2α. Methyl esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid.

16-phenoxy tetranor Prostaglandin F2α methyl ester
规格价格库存数量
500 μg
¥ 1,420
35日内发货
1 mg
¥ 2,650
35日内发货
5 mg
¥ 10,800
35日内发货
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产品介绍

生物活性
产品描述
Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF2α are used to modulate luteolysis and treat glaucoma. 16-phenoxy tetranor Prostaglandin F2α (16-phenoxy tetranor PGF2α) is a metabolically stable form of PGF2α containing a 16-phenoxy group at the ω-terminus. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α. 16-phenoxy tetranor PGF2α methyl ester is a lipophilic analog of 16-phenoxy tetranor PGF2α. Methyl esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid.
别名
16-phenoxy tetranor Prostaglandin F2α methyl ester
化学信息
分子量404.503
分子式C23H32O6
CAS No.51638-90-5
SmilesCOC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COc1ccccc1
储存&溶解度
存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息
DMSO: 100 mg/mL (247.22 mM), Sonication is recommended.
Ethanol: 100 mg/mL (247.22 mM), Sonication is recommended.
PBS (pH 7.2): 0.5 mg/mL (1.24 mM), Sonication is recommended.
DMF: 100 mg/mL (247.22 mM), Sonication is recommended.
溶液配制表
PBS (pH 7.2)/DMSO/Ethanol/DMF
1mg5mg10mg50mg
1 mM2.4722 mL12.3608 mL24.7217 mL123.6085 mL
DMSO/Ethanol/DMF
1mg5mg10mg50mg
5 mM0.4944 mL2.4722 mL4.9443 mL24.7217 mL
10 mM0.2472 mL1.2361 mL2.4722 mL12.3608 mL
20 mM0.1236 mL0.6180 mL1.2361 mL6.1804 mL
50 mM0.0494 mL0.2472 mL0.4944 mL2.4722 mL
100 mM0.0247 mL0.1236 mL0.2472 mL1.2361 mL
该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

16-phenoxy tetranor Prostaglandin F-2α methyl ester16phenoxy tetranor Prostaglandin F2α methyl ester16 phenoxy tetranor Prostaglandin F2α methyl ester
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