d5

SCH-23390 maleate (R-(+)-SCH-23390 maleate) 是多巴胺D1样受体选择性拮抗剂，与D1和D5受体结合的Ki 分别为 0.2 nM 和 0.3 nM。它也是人5-HT2C 受体激动剂，Ki 为 9.3 nM。它与5-HT2和5-HT1C 受体具有高亲和力。它还抑制 G 蛋白偶联的内向整流钾通道，IC50为 268 nM。

Tavapadon (CVL-751) 是一种具有口服活性，高选择性的多巴胺 D1/D5受体部分激动剂，它可有效促进运动并减少残疾，对帕金森氏病具有潜在的应用价值。

Rotigotine Hydrochloride (N-0924) 是多巴胺受体激动剂，是5-HT1A 受体的部分激动剂，以及α2B-肾上腺素受体的拮抗剂，具有抗帕金森病活性。

NGB 2904 是一种具有口服活性的、选择性的多巴胺(DA) D3受体拮抗剂，可用于具可卡因成瘾。

SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) 是一种选择性多巴胺 D1样受体拮抗剂，对 D1和 D5受体的Ki 分别为 0.2 和 0.3 nM。它还抑制 G 蛋白偶联的内向整流钾通道，IC50为 268 nM。它与5-HT2和5-HT1C 受体具有高亲和力，是人5-HT2C 受体激动剂，Ki 为 9.3 nM。

SKF-83566 是一种具有血脑渗透性和口服活性的 D1 样多巴胺受体拮抗剂和一种较弱的竞争性 5-HT2 受体拮抗剂，Ki 为 11 nM。它是竞争性多巴胺转运蛋白抑制剂，可用于研究帕金森氏症和对尼古丁渴望的缓解的相关研究。

carfenazine 靶向多巴胺受体，用于精神分裂症研究。

Aniline-D5是Aniline (T207053)的氘代同位素标记物，可用于同位素示踪。Aniline 通过铁过载和通过血红素加氧酶 1 上调诱导氧化应激对脾脏产生毒性，能够导致 p-IKKα 和 p-IKKβ 显着增加，进而增加 NF-κB 和 AP-1 结合活性。

6-beta-Naloxol-D5 hydrochloride is a deuterium-labeled opioid antagonist,closely related to naloxone,that serves as an effective compound in the field of chemical research.

Bimatoprost-D5 is a deuterium-labeled Bimatoprost. Bimatoprost (T2538) is a topical hypotensive agent frequently used for treating glaucoma and ocular hypertension.

Blonanserin-D5 is a deuterium-labeled Blonanserin. Blonanserin (T1180) (AD-5423) is a dopamine D2/5-HT2 receptor antagonist with an atypical antipsychotic effect.

Enalapril-D5 maleate is deuterium labeled Enalapril,which is an angiotensin converting enzyme (ACE)inhibitor.

Enalaprilat-D5 sodium is the deuterium labeled Enalaprilat,which is an angiotensin-converting enzyme (ACE)inhibitor.

Enalaprilat-D5 is the deuterium labeled Enalaprilat (T6340L),which is an angiotensin-converting enzyme (ACE) inhibitor.

Ethacrynic acid,a diuretic,functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels,facilitating the relaxation of airway smooth muscle (ASM)cells. It exhibits anti-inflammatory effects,notably reducing retinoid-induced ear edema in mice,and inhibits glutathione S-transferases (GSTs),making it a potent suppressor of the NF-kB signaling pathway. Additionally,ethacrynic acid modulates leukotriene formation. A variant,Ethacrynic acid-D5,is distinguished by its deuterium labeling.

Idelalisib-D5 isib D5 is a deuterium-labeled Idelalisib. Idelalisib (T8651) is a highly selective and orally bioavailable p110δ inhibitor.

Indoramin-D5 is a piperidine antiadrenergic agent. Indoramin (T61165)D5 is deuterium labeled Indoramin.

Ketorolac-D5是Ketorolac (T21412)的氘代标记化合物，可用于同位素示踪。Ketorolac是非甾体抗炎剂和COX-1与COX-2的抑制剂。

Nateglinide-D5 is a deuterium labeled Nateglinide (T1674).

Nepafenac-D5 is the deuterium labeled Nepafenac,which is a selective inhibitor of COX-2 .

Nimesulide D5 是非甾体抗炎药 Nimesulide 的氘代同位素标记衍生物，可用于药代动力学、代谢及吸收研究。Nimesulide 是一种有选择性的 COX-2 抑制剂，IC50 值为 70 nM-70 μM。 Nimesulide 具有抗炎、止痛、解热的作用。

Phenindione-D5 is deuterium labeled Phenindione (T0514),which functions as a Vitamin K antagonist.

(Rac)-Apremilast-D5 is a deuterium-labeled version of the enantiomer (Rac)-Apremilast (T21043),also known as (R)-CC-10004,which itself is one specific form of Apremilast.

(rel)-Tranylcypromine-D5 hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride. (rel)-Tranylcypromine hydrochloride is an irreversible,nonselective inhibitor of monoamine oxidase (MAO)used in the treatment of depression.