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顶部生物活性储存和溶解信息计算器

Anti-Phospho-NBN (Ser343) Antibody (5K712)

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Anti-Phospho-NBN (Ser343) Antibody (5K712)
产品编号 TMAC-03245
别名 p-NBN (Ser343), p-NBN (S343), Phospho-NBN (S343), p95 protein of the MRE11/RAD50 complex, p95, Nijmegen breakage syndrome protein 1, Nijmegen breakage syndrome 1, Nijmegen breakage syndrome, Nibrin, nibrin, NBS1, NBS 1, NBS, NBN (p-Ser343), NBN (p-S343), MGC87362, FLJ10155, Cell cycle regulatory protein p95, ATV, AT V2, AT V1

Anti-Phospho-NBN (S343) Antibody (5K712) 是一种 Rabbit 抗体，靶向 Phospho-NBN (S343)。Anti-Phospho-NBN (S343) Antibody (5K712) 可用于 WB,ICC/IF,IHC,IP。

Anti-Phospho-NBN (Ser343) Antibody (5K712)

Anti-Phospho-NBN (Ser343) Antibody (5K712)

Rating icon 还可以
Anti-Phospho-NBN (Ser343) Antibody (5K712)
产品编号 TMAC-03245 别名 p-NBN (Ser343), p-NBN (S343), Phospho-NBN (S343), p95 protein of the MRE11/RAD50 complex, p95, Nijmegen breakage syndrome protein 1, Nijmegen breakage syndrome 1, Nijmegen breakage syndrome, Nibrin, nibrin, NBS1, NBS 1, NBS, NBN (p-Ser343), NBN (p-S343), MGC87362, FLJ10155, Cell cycle regulatory protein p95, ATV, AT V2, AT V1

Anti-Phospho-NBN (S343) Antibody (5K712) 是一种 Rabbit 抗体，靶向 Phospho-NBN (S343)。Anti-Phospho-NBN (S343) Antibody (5K712) 可用于 WB,ICC/IF,IHC,IP。

规格价格库存数量
50 μL
¥ 1,490
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100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-NBN (Ser343) Antibody (5K712) 是一种 Rabbit 抗体，靶向 Phospho-NBN (Ser343)。Anti-Phospho-NBN (Ser343) Antibody (5K712) 可用于 WB,ICC/IF,IHC,IP。
别名p-NBN (Ser343), p-NBN (S343), Phospho-NBN (S343), p95 protein of the MRE11/RAD50 complex, p95, Nijmegen breakage syndrome protein 1, Nijmegen breakage syndrome 1, Nijmegen breakage syndrome, Nibrin, nibrin, NBS1, NBS 1, NBS, NBN (p-Ser343), NBN (p-S343), MGC87362, FLJ10155, Cell cycle regulatory protein p95, ATV, AT V2, AT V1
Ig Type
IgG
交叉反应
Human
验证活性
1. Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-Phospho-p95/NBS1 (S343) antibody. Counter stained with hematoxylin.
2. ICC staining Phospho-p95/NBS1 (S343) in PC-3M cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
应用
WB
ICC/IF
IHC
IP
推荐剂量
WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Nijmegen breakage syndrome (NBS) is characterized by extreme radiation sensitivity, chromosomal instability and cancer. These phenotypes are similar to those of ataxia telangiectasia mutated (ATM) disease, where there is a deficiency in a protein kinase that is activated by DNA damage, indicating that the NBS1 (Nibrin) and ATM proteins may participate in common pathways. Nibrin is specifically phosphorylated in response to gamma-radiation, ultraviolet light and exposure to hydroxyurea. The phosphorylation of Nibrin requires catalytically active ATM. ATM physically interacts with and phosphorylates Nibrin on Serine 343 both in vitro and in vivo. Serine 343 is phosphorylated in vitro by ATM and the modification of this residue in vivo is essential for the cellular response to DNA damage. This response includes S-phase checkpoint activation, formation of the NBS1/Mrel1/Rad50 nuclear foci and rescue of hypersensitivity to ionizing radiation.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
A synthesized phosphopeptide: human p95/NBS1 around the phosphorylation site of Ser343
抗原种属
human
Uniprot ID
O60934
化学信息
分子量Theoretical: 95 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pNBN (Ser343)pNBN (S343)NBN (pSer343)NBN (pS343)NBN (phospho-Ser343)NBN (phospho-S343)

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