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Anti-Phospho-HER3/ErbB3 (Tyr1289) Antibody (5D565)
还可以产品编号 TMAY-01654
Anti-Phospho-HER3/ErbB3 (Tyr1289) Antibody (5D565) 是一种 Rabbit 抗体，靶向 Phospho-HER3/ErbB3 (Tyr1289)。Anti-Phospho-HER3/ErbB3 (Tyr1289) Antibody (5D565) 可用于 WB。
Anti-Phospho-HER3/ErbB3 (Tyr1289) Antibody (5D565)
Anti-Phospho-HER3/ErbB3 (Tyr1289) Antibody (5D565)
还可以产品编号 TMAY-01654
Anti-Phospho-HER3/ErbB3 (Tyr1289) Antibody (5D565) 是一种 Rabbit 抗体，靶向 Phospho-HER3/ErbB3 (Tyr1289)。Anti-Phospho-HER3/ErbB3 (Tyr1289) Antibody (5D565) 可用于 WB。
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偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-HER3/ErbB3 (Tyr1289) Antibody (5D565) is a Rabbit antibody targeting Phospho-HER3/ErbB3 (Tyr1289). Anti-Phospho-HER3/ErbB3 (Tyr1289) Antibody (5D565) can be used in WB. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 5D565 |
| 交叉反应 | Human; Species predicted to react based on 100% sequence homology: cynomolgus |
| 验证活性 | 1. Western blot analysis of extracts from serum-starved MCF-7, untreated (-) or treated with neuregulin-1 (100 ng/mL, 5 min) using Phospho-HER3/ErbB3 (Tyr1289) rabbit monoclonal Antibody at 1:2000 dilution (upper), or Anti-HER3/ERBB3 Antibody, Rabbit Polyclonal at 1:2000 dilution (middle), or Beta-Tubulin Loading Control Antibody, Mouse MAb at 1:2000 dilution (lower) 2. Western blot analysis of extracts from serum-starved MCF-7, untreated (line A); treated with neuregulin-1(100ng/ml, 5min; +) (line B); treated with neuregulin-1 and λ-phosphatase (line C) using Phospho-HER3/ErbB3 (Tyr1289) rabbit monoclonal Antibody at 1:100000 dilution. (Validation Experiment) |
| 应用 | WB |
| 推荐剂量 | WB: 1:2000-1:20000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with a synthetic phosphopeptide corresponding to residues around Tyr1289 of the Human Phospho-HER3/ErbB3. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5 |
| 研究背景 | ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic phosphopeptide corresponding to residues around Tyr1289 of the Human Phospho-HER3/ErbB3 |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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