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Thiamine pyrophosphokinase (TPK) produces thiamine pyrophosphate, a cofactor for a number of enzymes, including pyruvate dehydrogenase and 2-ketoglutarate dehydrogenase. Episodic encephalopathy type thiamine metabolism dysfunction (OMIM 614458) due to TPK1 mutations is a recently described rare disorder. The genomic variations in the fetal and maternal TPK1 gene could contribute to the variability of birth weight in normal humans.

| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 μg | ¥ 472 | 6-8日内发货 | |
| 10 μg | ¥ 772 | 6-8日内发货 | |
| 20 μg | ¥ 1,270 | 5日内发货 | |
| 50 μg | ¥ 2,930 | 5日内发货 |
| 生物活性 | Kinase activity untested |
| 产品描述 | Thiamine pyrophosphokinase (TPK) produces thiamine pyrophosphate, a cofactor for a number of enzymes, including pyruvate dehydrogenase and 2-ketoglutarate dehydrogenase. Episodic encephalopathy type thiamine metabolism dysfunction (OMIM 614458) due to TPK1 mutations is a recently described rare disorder. The genomic variations in the fetal and maternal TPK1 gene could contribute to the variability of birth weight in normal humans. |
| 种属 | Human |
| 表达系统 | E. coli |
| 标签 | N-His |
| 蛋白编号 | AAH68460.1 |
| 别名 | THMD5,thiamin pyrophosphokinase 1,PP20,HTPK1 |
| 蛋白构建 | A DNA sequence encoding the human TPK1 (AAH68460.1) (Met1-Ser243) was expressed with a polyhistidine tag at the N-terminus. Predicted N terminal: His |
| 蛋白纯度 | > 90 % as determined by SDS-PAGE |
| 分子量 | 29.5 kDa (predicted); 27-32 kDa (reducing conditions) |
| 内毒素 | Please contact us for more information. |
| 蛋白性状 | Solution |
| 缓冲液 | Supplied as sterile PBS, pH 7.4. |
| 复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| 存储 | It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| 运输方式 | Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice. |
| 研究背景 | Thiamine pyrophosphokinase (TPK) produces thiamine pyrophosphate, a cofactor for a number of enzymes, including pyruvate dehydrogenase and 2-ketoglutarate dehydrogenase. Episodic encephalopathy type thiamine metabolism dysfunction (OMIM 614458) due to TPK1 mutations is a recently described rare disorder. The genomic variations in the fetal and maternal TPK1 gene could contribute to the variability of birth weight in normal humans. |