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顶部产品介绍化学信息储存和溶解信息计算器技术支持

CD58 Protein, Human, Recombinant (hFc)

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货号 TMPY-03408

别名 LFA-3, LFA3, CD58 molecule, CD58, ag3

CD58 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.1 kDa and the accession number is AAH05930.

CD58 Protein, Human, Recombinant (hFc)
其他形式的 “CD58 Protein, Human, Recombinant (hFc)”:
AG-3 Protein, Human, Recombinant (His)
AGR3 Protein, Mouse, Recombinant (His)
CD58 Protein, Human, Recombinant (His)
CD58 Protein, Cynomolgus, Recombinant (His)
AGR3 Protein, Human, Recombinant (mFc)

CD58 Protein, Human, Recombinant (hFc)

一键复制产品信息
Rating icon 还可以
SPR兼容缓冲液
货号 TMPY-03408 别名 LFA-3, LFA3, CD58 molecule, CD58, ag3

CD58 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.1 kDa and the accession number is AAH05930.

规格价格库存数量
5 μg
¥ 493
6-8日内发货
10 μg
¥ 790
6-8日内发货
20 μg
¥ 1,330
5日内发货
50 μg
¥ 2,580
5日内发货
100 μg
¥ 5,170
5日内发货
200 μg
¥ 7,730
5日内发货
500 μg
¥ 16,300
5日内发货
1 mg
¥ 33,700
5日内发货
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产品介绍

生物活性
产品描述
CD58 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.1 kDa and the accession number is AAH05930.
生物活性
Immobilized Human CD2, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Human CD58, hFc Tag with the EC50 of 0.32 μg/ml determined by ELISA (QC Test).
Human CD2, His Tag captured on CM5 Chip via anti-his antibody can bind Human CD58, hFc Tag with an affinity constant of 15.48 nM as determined in SPR assay (Biacore T200).
研究背景
Loss of CD58 is a common mechanism for tumor immune evasion in lymphoid malignancies. CD58 loss is known to occur due to both genetic and non-genetic causes; therefore, we hypothesized that restoring CD58 expression in lymphoma cells may be an effective treatment approach. EZH2 is involved in the epigenetic silencing of CD58 in lymphoma cells as a mechanism for tumor immune escape, and EZH2 inhibitors are able to restore epigenetically suppressed CD58 expression.
种属
Human
表达系统
HEK293 Cells
标签C-hFc
蛋白编号AAH05930
蛋白构建Phe29-Arg215
蛋白纯度
> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
蛋白性状Lyophilized powder
缓冲液Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
复溶方法Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名LFA-3, LFA3, CD58 molecule, CD58, ag3
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
化学信息
分子量48.1 kDa (predicted); 65-75 kDa (reducing conditions)
储存&溶解度
运输方式In general, Lyophilized powders are shipping with blue ice.
存储It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

计算器

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剂量转换

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技术支持

请阅读 重组蛋白用户指南 了解更多具体信息.

关键词

LFA 3CD-58CD 58
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