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EDAR Protein, Human, Recombinant (His)

产品编号 TMPY-01637

别名: ED3, DL, ectodysplasin A receptor, ED1R, EDA1R, HRM1, EDA-A1R, EDA3, ED5, ECTD10A, ECTD10B

EDAR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19 kDa and the accession number is Q9UNE0-1.

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EDAR Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 2,530		5日内发货

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参考文献

生物活性	Testing in progress
产品描述	EDAR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19 kDa and the accession number is Q9UNE0-1.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q9UNE0-1
别名	ED3, DL, ectodysplasin A receptor, ED1R, EDA1R, HRM1, EDA-A1R, EDA3, ED5, ECTD10A, ECTD10B
蛋白构建	The Human EDAR (NP_071731.1) extracellular domain (Met 1-Ile 189) was fused with a polyhistidine tag at the C-terminus.
蛋白纯度	> 96 % as determined by SDS-PAGE
分子量	19 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Tumor necrosis factor receptor superfamily member EDAR is a Single-pass type I membrane protein. Edar was expressed reiteratively in signaling centers regulating key steps in morphogenesis. activin signaling from mesenchyme induces the expression of the TNF receptor edar in the epithelial signaling centers, thus making them responsive to Wnt-induced ectodysplasin from the nearby ectoderm. This is the first demonstration of integration of the Wnt, activin, and TNF signaling pathways. Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA), also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.

参考文献

1. Elomaa O, et al. (2001) Ectodysplasin is released by proteolytic shedding and binds to the EDAR protein. Hum Mol Genet. 10 (9): 953-62. 2. Koppinen P, et al. (2001) Signaling and subcellular localization of the TNF receptor Edar. Exp Cell Res. 269 (2): 180-92. 3. Chassaing N, et al. (2006) Mutations in EDAR account for one-quarter of non-ED1-related hypohidrotic ectodermal dysplasia. Hu. Mutat. 27 (3): 255-9.

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Keywords

EDAR Protein, Human, Recombinant (His) ED3 DL HRM 1 ED 5 ectodysplasin A receptor ED 3 ED1R EDA1R HRM1 ED-3 EDA-A1R EDA 3 ED-5 HRM-1 EDA3 ED5 ECTD10A ECTD10B EDA-3 recombinant recombinant-proteins proteins protein

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