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Anti-SRD5A1 Polyclonal Antibody 2

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货号 TMAB-13151

Anti-SRD5A1 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 SRD5A1。Anti-SRD5A1 Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。

Anti-SRD5A1 Polyclonal Antibody 2

Anti-SRD5A1 Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
货号 TMAB-13151

Anti-SRD5A1 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 SRD5A1。Anti-SRD5A1 Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

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产品描述
Anti-SRD5A1 Polyclonal Antibody 2 is a Rabbit antibody targeting SRD5A1. Anti-SRD5A1 Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential).
组织特异性Liver and prostate (at a low level).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Steroid 5a-Reductase is an important enzyme in androgen physiology because it catalyzes the conversion of testosterone into the more potent 5a-dihydro-testosterone, which mediates androgen effects on target tissues. The enzyme exists as two isoforms: type 1, which is expressed mainly in the skin; and type 2, which is expressed mainly in the prostate. In cultured human skin cells, 5a-Reductase 1 shows heterogeneity of protein, and has different levels of transcriptional and translational expression. 5a-Reductase 1 is expressed in all portions of the hair follicle, whereas 5a-Reductase 2 is expressed only in mesenchymal portions. In addition, 5a-Reductase 1 is mainly expressed in human breast carcinoma and may play a role in the in situ production and actions of the potent androgen 5a-dihydrotestosterone, including inhibition of cancer cell proliferation in hormone-dependent human breast carcinoma. The 5a-Reductase-3a-hydroxysteroid dehydrogenase complex is present in the human brain, suggesting that the complex may be involved in the synthesis of neuroactive steroids or the catabolism of neurotoxic steroids.
抗原信息
免疫原
KLH conjugated synthetic peptide: human SRD5A1
抗原种属
Human
基因名称
SRD5A1
基因ID
6715
蛋白名称
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Uniprot ID
P18405
功能
Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
化学信息
分子量Theoretical: 29 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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