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CD20 Protein, Human, Recombinant (aa 213-297, His)

产品编号 TMPY-02819

别名: Bp35, MS4A2, LEU-16, CVID5, MS4A1, membrane-spanning 4-domains, subfamily A, member 1, B1, CD20, S7

CD20 Protein, Human, Recombinant (aa 213-297, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 12.1 kDa and the accession number is A0A024R507.

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CD20 Protein, Human, Recombinant (aa 213-297, His)

规格	价格/CNY		货期	数量
20 μg	￥ 2,270		5日内发货

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生物活性	Testing in progress
产品描述	CD20 Protein, Human, Recombinant (aa 213-297, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 12.1 kDa and the accession number is A0A024R507.

种属	Human
表达系统	HEK293 Cells
标签	N-His
蛋白编号	A0A024R507
别名	Bp35, MS4A2, LEU-16, CVID5, MS4A1, membrane-spanning 4-domains, subfamily A, member 1, B1, CD20, S7
蛋白构建	The Human CD20 (NP_068769.2) (Glu213-Pro297) was expressed, with an N-terminal polyhistidine tag.
蛋白纯度	> 83 % as determined by SDS-PAGE
分子量	12.1 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	CD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed in all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule that plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections, and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells are usually in the normal range but can be very low.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Tedder TF,et al.(1988) Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. Proc Natl Acad Sci. 85(1): 208-12. 2. Cragg MS, et al. (2005) The biology of CD20 and its potential as a target for mAb therapy. Curr Dir Autoimmun. 8: 140-74.. 3. Polyak MJ,et al.(2003) A cholesterol-dependent CD20 epitope detected by the FMC7 antibody. Leukemia. 17(7): 1384-9.

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Keywords

CD20 Protein, Human, Recombinant (aa 213-297, His) Bp35 CD 20 CD-20 MS4A2 LEU-16 LEU16 S 7 CVID 5 CVID5 MS4A1 membrane-spanning 4-domains, subfamily A, member 1 LEU 16 CVID-5 S-7 B1 B 1 CD20 S7 B-1 recombinant recombinant-proteins proteins protein

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