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Anti-Alpha-2-macroglobulin Antibody (4X593)
还可以产品编号 TMAY-01377
Anti-Alpha-2-macroglobulin Antibody (4X593) 是一种 Rabbit 抗体，靶向 Alpha-2-macroglobulin。Anti-Alpha-2-macroglobulin Antibody (4X593) 可用于 ELISA。
Anti-Alpha-2-macroglobulin Antibody (4X593)
Anti-Alpha-2-macroglobulin Antibody (4X593)
还可以产品编号 TMAY-01377
Anti-Alpha-2-macroglobulin Antibody (4X593) 是一种 Rabbit 抗体，靶向 Alpha-2-macroglobulin。Anti-Alpha-2-macroglobulin Antibody (4X593) 可用于 ELISA。
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抗原信息
| 产品描述 | Anti-Alpha-2-macroglobulin Antibody (4X593) is a Rabbit antibody targeting Alpha-2-macroglobulin. Anti-Alpha-2-macroglobulin Antibody (4X593) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 4X593 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human alpha-2-macroglobulin / A2M (rh alpha-2-macroglobulin / A2M; TMPY-02063; NP_000005.2; Met1-Ala1474). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | alpha-2-macroglobulin, also known as α2-macroglobulin (α2M and A2M), is an abundant protein of the plasma of vertebrates and members of several invertebrate phyla and functions as a broad-spectrum protease-binding protein. alpha-2-macroglobulin is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis. alpha-2-macroglobulin is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently, it has been reported that numerous growth factors, cytokines and hormones bind to alpha 2M through diverse mechanisms. A2M is also produced in the brain where it binds multiple extracellular ligands and is internalized by neurons and astrocytes. In the brain of Alzheimer's disease (AD) patients, A2M has been localized to diffuse amyloid plaques. A2M also binds soluble beta-amyloid, of which it mediates degradation. Protease-conjugated alpha2-macroglobulin is selectively bound by cells contacting the body fluids and alpha2-macroglobulin and its protease cargo are then internalized and degraded in secondary lysosomes of those cells. In addition to this function as an agent for protease clearance, alpha2-macroglobulin binds a variety of other ligands, including several peptide growth factors and modulates the activity of a lectin-dependent cytolytic pathway in arthropods. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human alpha-2-macroglobulin / A2M Protein (TMPY-02063) |
| 抗原种属 | Human |
| 研究领域 | Serine Proteases and Regulators |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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