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Anti-CD20 Antibody (1F875)
还可以产品编号 TMAY-01443
Anti-CD20 Antibody (1F875) 是一种 Mouse 抗体，靶向 CD20。Anti-CD20 Antibody (1F875) 可用于 IHC-P。
Anti-CD20 Antibody (1F875)
Anti-CD20 Antibody (1F875)
还可以产品编号 TMAY-01443
Anti-CD20 Antibody (1F875) 是一种 Mouse 抗体，靶向 CD20。Anti-CD20 Antibody (1F875) 可用于 IHC-P。
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抗原信息
| 产品描述 | Anti-CD20 Antibody (1F875) is a Mouse antibody targeting CD20. Anti-CD20 Antibody (1F875) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 1F875 |
| 交叉反应 | Human, Cynomolgus |
| 验证活性 | 1. Immunochemical staining CD20 in human tonsil with mouse monoclonal antibody at 1:60 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining CD20 in human lymphoma with mouse monoclonal antibody at 1:60 dilution, formalin-fixed paraffin embedded sections. 3. Immunochemical staining CD20 in cynomolgus spleen with mouse monoclonal antibody at 1:60 dilution, formalin-fixed paraffin embedded sections. 4. Immunochemical staining CD20 in cynomolgus lymph node with mouse monoclonal antibody at 1:60 dilution, formalin-fixed paraffin embedded sections. |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:30-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD20/MS4A1 (rh CD20/MS4A1; TMPY-02819; NP_068769.2; Glu213-Pro297). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | CD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed in all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule that plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections, and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells are usually in the normal range but can be very low.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CD20/MS4A1 Protein (TMPY-02819) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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