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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-CD59 Polyclonal Antibody

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货号 TMAB-04033

Anti-CD59 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CD59。Anti-CD59 Polyclonal Antibody 可用于 FCM。

Anti-CD59 Polyclonal Antibody

Anti-CD59 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-04033

Anti-CD59 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 CD59。Anti-CD59 Polyclonal Antibody 可用于 FCM。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-CD59 Polyclonal Antibody is a Rabbit antibody targeting CD59. Anti-CD59 Polyclonal Antibody can be used in FCM.
Ig Type
IgG
反应种属
Human
应用FCM
推荐剂量
FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Soluble form found in a number of tissues.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
KLH conjugated synthetic peptide: human CD59
抗原种属
Human
基因名称
CD59
基因ID
966
蛋白名称
CD59 glycoprotein
Uniprot ID
P13987
功能
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
化学信息
分子量Theoretical: 9 kDa. Actual: 19-25 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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