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Anti-SQSTM1/P62 Antibody (4D597)

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货号 TMAB-13146

Anti-SQSTM1/P62 Antibody (4D597) 是一种 Rabbit 抗体,靶向 SQSTM1/P62。Anti-SQSTM1/P62 Antibody (4D597) 可用于 WB,IHC-P,IHC-Fr,IF,FCM,ICC/IF,IP。

Anti-SQSTM1/P62 Antibody (4D597)

Anti-SQSTM1/P62 Antibody (4D597)

一键复制产品信息
Rating icon 还可以
货号 TMAB-13146

Anti-SQSTM1/P62 Antibody (4D597) 是一种 Rabbit 抗体,靶向 SQSTM1/P62。Anti-SQSTM1/P62 Antibody (4D597) 可用于 WB,IHC-P,IHC-Fr,IF,FCM,ICC/IF,IP。

规格价格库存数量
25 μL
¥ 795
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍


生物活性
产品描述
Anti-SQSTM1/P62 Antibody (4D597) is a Rabbit antibody targeting SQSTM1/P62. Anti-SQSTM1/P62 Antibody (4D597) can be used in WB,IHC-P,IHC-Fr,IF,FCM,ICC/IF,IP.
Ig Type
IgG
克隆号
4D597
反应种属
Human
应用WBIHC-PIHC-FrIFFCMICC/IFIP
推荐剂量
WB: 1:500-2000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200; FCM: 1:50-100; ICC/IF: 1:50-200; IP: 1:20-50
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Late endosome. Nucleus. Sarcomere (By similarity). In cardiac muscles localizes to the sarcomeric band (By similarity). Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma.
组织特异性Ubiquitously expressed.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
抗原信息
免疫原
A synthesized peptide: human Sequestosome 1
抗原种属
Human
基因名称
SQSTM1
基因ID
蛋白名称
Sequestosome-1
Uniprot ID
功能
Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
化学信息
分子量Theoretical: 48 kDa. Actual: 62 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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