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顶部生物活性储存和溶解信息计算器

Anti-Phospho-RAD51 (Thr309) Polyclonal Antibody 2

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产品编号 TMAB-11208

Anti-Phospho-RAD51 (Thr309) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-RAD51 (Thr309)。Anti-Phospho-RAD51 (Thr309) Polyclonal Antibody 2 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM。

Anti-Phospho-RAD51 (Thr309) Polyclonal Antibody 2

Anti-Phospho-RAD51 (Thr309) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-11208

Anti-Phospho-RAD51 (Thr309) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-RAD51 (Thr309)。Anti-Phospho-RAD51 (Thr309) Polyclonal Antibody 2 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-RAD51 (Thr309) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-RAD51 (Thr309). Anti-Phospho-RAD51 (Thr309) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM.
Ig Type
IgG
交叉反应
Human,Mouse (predicted:Rat,Chicken,Dog,Pig,Cow,Rabbit,Sheep)
应用WBIHC-PIHC-FrICC/IFIFFCM
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion matrix. Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage. DNA damage induces an increase in nuclear levels.
组织特异性Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human RAD51 around the phosphorylation site of Thr309
抗原种属
Human
基因名称
RAD51
基因ID
5888
蛋白名称
DNA repair protein RAD51 homolog 1
Uniprot ID
Q06609
功能
Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.
化学信息
分子量Theoretical: 37 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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